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Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function.
Biochem J. 2019 Nov 15;476(21):3401-3411. doi: 10.1042/BCJ20190687.
Biochem J. 2019.
PMID: 31652301
Free PMC article.
Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions.
Medina-Medina I, García-Beltrán P, de la Mora-de la Mora I, Oria-Hernández J, Millot G, Fahraeus R, Reyes-Vivas H, Sampedro JG, Olivares-Illana V.
Medina-Medina I, et al.
Mol Cell Biol. 2016 Jul 29;36(16):2195-205. doi: 10.1128/MCB.00113-16. Print 2016 Aug 15.
Mol Cell Biol. 2016.
PMID: 27215386
Free PMC article.
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p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction.
Medina-Medina I, Martínez-Sánchez M, Hernández-Monge J, Fahraeus R, Muller P, Olivares-Illana V.
Medina-Medina I, et al.
Protein Sci. 2018 May;27(5):976-986. doi: 10.1002/pro.3405. Epub 2018 Mar 25.
Protein Sci. 2018.
PMID: 29524278
Free PMC article.
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Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism.
Calderon-González KG, Medina-Medina I, Haronikova L, Hernychova L, Bonczek O, Uhrik L, Hrabal V, Vojtesek B, Fahraeus R, Hernández-Monge J, Olivares-Illana V.
Calderon-González KG, et al. Among authors: medina medina i.
Biosci Rep. 2022 Jul 29;42(7):BSR20220186. doi: 10.1042/BSR20220186.
Biosci Rep. 2022.
PMID: 35674210
Free PMC article.
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MDM2 regulates RB levels during genotoxic stress.
Hernandez-Monge J, Martínez-Sánchez M, Rousset-Roman A, Medina-Medina I, Olivares-Illana V.
Hernandez-Monge J, et al. Among authors: medina medina i.
EMBO Rep. 2021 Jan 7;22(1):e50615. doi: 10.15252/embr.202050615. Epub 2020 Nov 13.
EMBO Rep. 2021.
PMID: 33185004
Free PMC article.
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Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB.
Hernández-Monge J, Rousset-Roman AB, Medina-Medina I, Olivares-Illana V.
Hernández-Monge J, et al. Among authors: medina medina i.
Genes Cancer. 2016 Sep;7(9-10):278-287. doi: 10.18632/genesandcancer.120.
Genes Cancer. 2016.
PMID: 28050229
Free PMC article.
Review.
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