Smith KJ - Search Results

1

Analgesic and Respiratory Depressant Effects of R-dihydroetorphine: A Pharmacokinetic-Pharmacodynamic Analysis in Healthy Male Volunteers.

Olofsen E, Boom M, Sarton E, van Velzen M, Baily P, Smith KJ, Oksche A, Dahan A, Niesters M. Olofsen E, et al. Among authors: smith kj. Anesthesiology. 2019 Dec;131(6):1327-1339. doi: 10.1097/ALN.0000000000002991. Anesthesiology. 2019. PMID: 31651529 Free article. Clinical Trial.

2

Pharmacokinetics and brain σ1 receptor occupancy of MR309, a selective σ1 receptor antagonist.

Rabiner EA, Smith K, Bennett C, Rizzo G, Lewis Y, Mundin G, Dooner H, Oksche A. Rabiner EA, et al. Br J Clin Pharmacol. 2022 Feb;88(4):1644-1654. doi: 10.1111/bcp.14952. Epub 2022 Feb 3. Br J Clin Pharmacol. 2022. PMID: 34156715 Free article.

3

Single- and multiple-dose pharmacokinetic evaluation of oxycodone and naloxone in an opioid agonist/antagonist prolonged-release combination in healthy adult volunteers.

Smith K, Hopp M, Mundin G, Leyendecker P, Bailey P, Grothe B, Uhl R, Reimer K. Smith K, et al. Clin Ther. 2008 Nov;30(11):2051-68. doi: 10.1016/j.clinthera.2008.11.008. Clin Ther. 2008. PMID: 19108793 Clinical Trial.

4

Low absolute bioavailability of oral naloxone in healthy subjects.

Smith K, Hopp M, Mundin G, Bond S, Bailey P, Woodward J, Bell D. Smith K, et al. Int J Clin Pharmacol Ther. 2012 May;50(5):360-7. doi: 10.5414/cp201646. Int J Clin Pharmacol Ther. 2012. PMID: 22541841 Clinical Trial.

5

Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study.

McDonald R, Lorch U, Woodward J, Bosse B, Dooner H, Mundin G, Smith K, Strang J. McDonald R, et al. Addiction. 2018 Mar;113(3):484-493. doi: 10.1111/add.14033. Epub 2017 Nov 16. Addiction. 2018. PMID: 29143400 Free PMC article. Clinical Trial.

6

The Effect of Food on Tramadol and Celecoxib Bioavailability Following Oral Administration of Co-Crystal of Tramadol-Celecoxib (CTC): A Randomised, Open-Label, Single-Dose, Crossover Study in Healthy Volunteers.

Encina G, Encabo M, Escriche M, Lahjou M, Sicard E, Smith K, Gascon N, Plata-Salamán C, Videla S. Encina G, et al. Clin Drug Investig. 2018 Sep;38(9):819-827. doi: 10.1007/s40261-018-0672-y. Clin Drug Investig. 2018. PMID: 30008052 Free PMC article. Clinical Trial.

7

Naloxone as part of a prolonged release oxycodone/naloxone combination reduces oxycodone-induced slowing of gastrointestinal transit in healthy volunteers.

Smith K, Hopp M, Mundin G, Bond S, Bailey P, Woodward J, Palaniappan K, Church A, Limb M, Connor A. Smith K, et al. Expert Opin Investig Drugs. 2011 Apr;20(4):427-39. doi: 10.1517/13543784.2011.563236. Expert Opin Investig Drugs. 2011. PMID: 21395483 Clinical Trial.

8

Co-crystal of tramadol-celecoxib: preclinical and clinical evaluation of a novel analgesic.

Gascon N, Almansa C, Merlos M, Miguel Vela J, Encina G, Morte A, Smith K, Plata-Salamán C. Gascon N, et al. Expert Opin Investig Drugs. 2019 May;28(5):399-409. doi: 10.1080/13543784.2019.1612557. Epub 2019 May 3. Expert Opin Investig Drugs. 2019. PMID: 31023091 Review.

9

Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach.

Reimer K, Hopp M, Zenz M, Maier C, Holzer P, Mikus G, Bosse B, Smith K, Buschmann-Kramm C, Leyendecker P. Reimer K, et al. Pharmacology. 2009;83(1):10-7. doi: 10.1159/000165778. Epub 2008 Oct 28. Pharmacology. 2009. PMID: 18957874 Review.

10

Pharmacokinetics of concentrated naloxone nasal spray over first 30 minutes post-dosing: analysis of suitability for opioid overdose reversal.

Mundin G, McDonald R, Smith K, Harris S, Strang J. Mundin G, et al. Addiction. 2017 Sep;112(9):1647-1652. doi: 10.1111/add.13849. Epub 2017 May 28. Addiction. 2017. PMID: 28430384 Clinical Trial.

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