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p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.
Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE. Loonat AA, et al. Among authors: tilgner k. FASEB J. 2019 Dec;33(12):13131-13144. doi: 10.1096/fj.201701545R. Epub 2019 Oct 22. FASEB J. 2019. PMID: 31638431 Free PMC article.
Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.
Collier AJ, Bendall A, Fabian C, Malcolm AA, Tilgner K, Semprich CI, Wojdyla K, Nisi PS, Kishore K, Roamio Franklin VN, Mirshekar-Syahkal B, D'Santos C, Plath K, Yusa K, Rugg-Gunn PJ. Collier AJ, et al. Among authors: tilgner k. Sci Adv. 2022 Mar 25;8(12):eabk0013. doi: 10.1126/sciadv.abk0013. Epub 2022 Mar 25. Sci Adv. 2022. PMID: 35333572 Free PMC article.
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program.
El-Khairi R, Olszanowski E, Muraro D, Madrigal P, Tilgner K, Chhatriwala M, Vyas S, Chia CY, Vallier L, Rodríguez-Seguí SA. El-Khairi R, et al. Among authors: tilgner k. Stem Cell Reports. 2021 Sep 14;16(9):2289-2304. doi: 10.1016/j.stemcr.2021.07.018. Epub 2021 Aug 26. Stem Cell Reports. 2021. PMID: 34450036 Free PMC article.
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
Melguizo-Sanchis D, Xu Y, Taheem D, Yu M, Tilgner K, Barta T, Gassner K, Anyfantis G, Wan T, Elango R, Alharthi S, El-Harouni AA, Przyborski S, Adam S, Saretzki G, Samarasinghe S, Armstrong L, Lako M. Melguizo-Sanchis D, et al. Among authors: tilgner k. Cell Death Dis. 2018 Jan 26;9(2):128. doi: 10.1038/s41419-017-0141-1. Cell Death Dis. 2018. PMID: 29374141 Free PMC article.
The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.
Zhu L, Gomez-Duran A, Saretzki G, Jin S, Tilgner K, Melguizo-Sanchis D, Anyfantis G, Al-Aama J, Vallier L, Chinnery P, Lako M, Armstrong L. Zhu L, et al. Among authors: tilgner k. J Cell Biol. 2016 Oct 24;215(2):187-202. doi: 10.1083/jcb.201601061. Epub 2016 Oct 17. J Cell Biol. 2016. PMID: 27810911 Free PMC article.
An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes.
Jiang Y, Habibollah S, Tilgner K, Collin J, Barta T, Al-Aama JY, Tesarov L, Hussain R, Trafford AW, Kirkwood G, Sernagor E, Eleftheriou CG, Przyborski S, Stojković M, Lako M, Keavney B, Armstrong L. Jiang Y, et al. Among authors: tilgner k. Stem Cells Transl Med. 2014 Apr;3(4):416-23. doi: 10.5966/sctm.2013-0105. Epub 2014 Mar 3. Stem Cells Transl Med. 2014. PMID: 24591732 Free PMC article.
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