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Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters.
Zhang K, Du Y, Si Z, Liu Y, Turvey ME, Raju C, Keogh D, Ruan L, Jothy SL, Reghu S, Marimuthu K, De PP, Ng OT, Mediavilla JR, Kreiswirth BN, Chi YR, Ren J, Tam KC, Liu XW, Duan H, Zhu Y, Mu Y, Hammond PT, Bazan GC, Pethe K, Chan-Park MB. Zhang K, et al. Among authors: pethe k. Nat Commun. 2019 Oct 21;10(1):4792. doi: 10.1038/s41467-019-12702-8. Nat Commun. 2019. PMID: 31636263 Free PMC article.
Designer broad-spectrum polyimidazolium antibiotics.
Zhong W, Shi Z, Mahadevegowda SH, Liu B, Zhang K, Koh CH, Ruan L, Chen Y, Zeden MS, Pee CJE, Marimuthu K, De PP, Ng OT, Zhu Y, Chi YR, Hammond PT, Yang L, Gan YH, Pethe K, Greenberg EP, Gründling A, Chan-Park MB. Zhong W, et al. Among authors: pethe k. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31376-31385. doi: 10.1073/pnas.2011024117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229526 Free PMC article.
Nanoparticles of Short Cationic Peptidopolysaccharide Self-Assembled by Hydrogen Bonding with Antibacterial Effect against Multidrug-Resistant Bacteria.
Hou Z, Shankar YV, Liu Y, Ding F, Subramanion JL, Ravikumar V, Zamudio-Vázquez R, Keogh D, Lim H, Tay MYF, Bhattacharjya S, Rice SA, Shi J, Duan H, Liu XW, Mu Y, Tan NS, Tam KC, Pethe K, Chan-Park MB. Hou Z, et al. Among authors: pethe k. ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38288-38303. doi: 10.1021/acsami.7b12120. Epub 2017 Oct 26. ACS Appl Mater Interfaces. 2017. PMID: 29028315
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WY, Patel V, Beer D, Walker JR, Duraiswamy J, Jiricek J, Keller TH, Chatterjee A, Tan MP, Ujjini M, Rao SP, Camacho L, Bifani P, Mak PA, Ma I, Barnes SW, Chen Z, Plouffe D, Thayalan P, Ng SH, Au M, Lee BH, Tan BH, Ravindran S, Nanjundappa M, Lin X, Goh A, Lakshminarayana SB, Shoen C, Cynamon M, Kreiswirth B, Dartois V, Peters EC, Glynne R, Brenner S, Dick T. Pethe K, et al. Nat Commun. 2010 Aug 24;1(5):57. doi: 10.1038/ncomms1060. Nat Commun. 2010. PMID: 20975714 Free PMC article.
Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer.
Scherr N, Bieri R, Thomas SS, Chauffour A, Kalia NP, Schneide P, Ruf MT, Lamelas A, Manimekalai MSS, Grüber G, Ishii N, Suzuki K, Tanner M, Moraski GC, Miller MJ, Witschel M, Jarlier V, Pluschke G, Pethe K. Scherr N, et al. Among authors: pethe k. Nat Commun. 2018 Dec 18;9(1):5370. doi: 10.1038/s41467-018-07804-8. Nat Commun. 2018. PMID: 30560872 Free PMC article.
120 results