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Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.
Abate C, Niso M, Lacivita E, Mosier PD, Toscano A, Perrone R. Abate C, et al. Among authors: mosier pd. J Med Chem. 2011 Feb 24;54(4):1022-32. doi: 10.1021/jm1013133. Epub 2011 Jan 13. J Med Chem. 2011. PMID: 21229979
Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opioid receptor selective antagonists.
Zaidi SA, Arnatt CK, He H, Selley DE, Mosier PD, Kellogg GE, Zhang Y. Zaidi SA, et al. Among authors: mosier pd. Bioorg Med Chem. 2013 Nov 1;21(21):6405-13. doi: 10.1016/j.bmc.2013.08.042. Epub 2013 Sep 4. Bioorg Med Chem. 2013. PMID: 24055076 Free PMC article.
47 results