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Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition.
Denton TT, Srivastava P, Xia Z, Chen G, Watson CJW, Wynd A, Lazarus P. Denton TT, et al. Among authors: lazarus p. J Med Chem. 2018 Aug 23;61(16):7065-7086. doi: 10.1021/acs.jmedchem.8b00084. Epub 2018 Aug 1. J Med Chem. 2018. PMID: 29995408 Free PMC article.
Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes.
Perez-Paramo YX, Chen G, Ashmore JH, Watson CJW, Nasrin S, Adams-Haduch J, Wang R, Gao YT, Koh WP, Yuan JM, Lazarus P. Perez-Paramo YX, et al. Among authors: lazarus p. Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):311-320. doi: 10.1158/1055-9965.EPI-18-0669. Epub 2018 Oct 31. Cancer Epidemiol Biomarkers Prev. 2019. PMID: 30381441 Free PMC article.
Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p.
Sutliff AK, Watson CJW, Chen G, Lazarus P. Sutliff AK, et al. Among authors: lazarus p. J Pharmacol Exp Ther. 2019 May;369(2):234-243. doi: 10.1124/jpet.118.255935. Epub 2019 Mar 8. J Pharmacol Exp Ther. 2019. PMID: 30850392 Free PMC article.
286 results