Freundlich JS - Search Results

1

Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis.

Wang X, Perryman AL, Li SG, Paget SD, Stratton TP, Lemenze A, Olson AJ, Ekins S, Kumar P, Freundlich JS. Wang X, et al. Among authors: freundlich js. ACS Infect Dis. 2019 Dec 13;5(12):2148-2163. doi: 10.1021/acsinfecdis.9b00295. Epub 2019 Nov 5. ACS Infect Dis. 2019. PMID: 31625383 Free PMC article.

2

Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.

Ekins S, Freundlich JS, Choi I, Sarker M, Talcott C. Ekins S, et al. Among authors: freundlich js. Trends Microbiol. 2011 Feb;19(2):65-74. doi: 10.1016/j.tim.2010.10.005. Epub 2010 Dec 2. Trends Microbiol. 2011. PMID: 21129975 Free PMC article. Review.

3

Essential metabolites of Mycobacterium tuberculosis and their mimics.

Lamichhane G, Freundlich JS, Ekins S, Wickramaratne N, Nolan ST, Bishai WR. Lamichhane G, et al. Among authors: freundlich js. mBio. 2011 Feb 1;2(1):e00301-10. doi: 10.1128/mBio.00301-10. mBio. 2011. PMID: 21285434 Free PMC article.

4

In silico repositioning of approved drugs for rare and neglected diseases.

Ekins S, Williams AJ, Krasowski MD, Freundlich JS. Ekins S, et al. Among authors: freundlich js. Drug Discov Today. 2011 Apr;16(7-8):298-310. doi: 10.1016/j.drudis.2011.02.016. Epub 2011 Mar 1. Drug Discov Today. 2011. PMID: 21376136 Review.

5

Validating new tuberculosis computational models with public whole cell screening aerobic activity datasets.

Ekins S, Freundlich JS. Ekins S, et al. Among authors: freundlich js. Pharm Res. 2011 Aug;28(8):1859-69. doi: 10.1007/s11095-011-0413-x. Epub 2011 Mar 10. Pharm Res. 2011. PMID: 21547522

6

Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosis.

Sarker M, Talcott C, Madrid P, Chopra S, Bunin BA, Lamichhane G, Freundlich JS, Ekins S. Sarker M, et al. Among authors: freundlich js. Pharm Res. 2012 Aug;29(8):2115-27. doi: 10.1007/s11095-012-0741-5. Epub 2012 Apr 4. Pharm Res. 2012. PMID: 22477069 Free PMC article.

7

Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery.

Ekins S, Reynolds RC, Kim H, Koo MS, Ekonomidis M, Talaue M, Paget SD, Woolhiser LK, Lenaerts AJ, Bunin BA, Connell N, Freundlich JS. Ekins S, et al. Among authors: freundlich js. Chem Biol. 2013 Mar 21;20(3):370-8. doi: 10.1016/j.chembiol.2013.01.011. Chem Biol. 2013. PMID: 23521795 Free PMC article.

8

Computational models for tuberculosis drug discovery.

Ekins S, Freundlich JS. Ekins S, et al. Among authors: freundlich js. Methods Mol Biol. 2013;993:245-62. doi: 10.1007/978-1-62703-342-8_16. Methods Mol Biol. 2013. PMID: 23568475 Review.

9

Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models.

Ekins S, Reynolds RC, Franzblau SG, Wan B, Freundlich JS, Bunin BA. Ekins S, et al. Among authors: freundlich js. PLoS One. 2013 May 7;8(5):e63240. doi: 10.1371/journal.pone.0063240. Print 2013. PLoS One. 2013. PMID: 23667592 Free PMC article.

10

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.

Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D. Wilson R, et al. Among authors: freundlich js. Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16. Nat Chem Biol. 2013. PMID: 23770708 Free PMC article.

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