Shuto S - Search Results

1

Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.

Yamamoto K, Tamura T, Nakamura R, Hosoe S, Matsubara M, Nagata K, Kodaira H, Uemori T, Takahashi Y, Suzuki M, Saito JI, Ueno K, Shuto S. Yamamoto K, et al. Among authors: shuto s. Bioorg Med Chem. 2019 Nov 15;27(22):115122. doi: 10.1016/j.bmc.2019.115122. Epub 2019 Sep 16. Bioorg Med Chem. 2019. PMID: 31623970 Free article.

2

Nucleosides and nucleotides--CXXXVII. Antitumor phospholipids with 5-fluorouridine as a cytotoxic polar-head: synthesis of 5'-phosphatidyl-5-fluorouridines by phospholipase D-catalyzed transphosphatidylation.

Shuto S, Itoh H, Sakai A, Nakagami K, Imamura S, Matsuda A. Shuto S, et al. Bioorg Med Chem. 1995 Mar;3(3):235-43. doi: 10.1016/0968-0896(95)00003-y. Bioorg Med Chem. 1995. PMID: 7606385

3

Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and -uracil1.

Hattori H, Nozawa E, Iino T, Yoshimura Y, Shuto S, Shimamoto Y, Nomura M, Fukushima M, Tanaka M, Sasaki T, Matsuda A. Hattori H, et al. Among authors: shuto s. J Med Chem. 1998 Jul 16;41(15):2892-902. doi: 10.1021/jm9801814. J Med Chem. 1998. PMID: 9667977

4

Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'alpha-C-branched-chain sugar pyrimidine nucleosides.

Nomura M, Shuto S, Tanaka M, Sasaki T, Mori S, Shigeta S, Matsuda A. Nomura M, et al. Among authors: shuto s. J Med Chem. 1999 Jul 29;42(15):2901-8. doi: 10.1021/jm990050i. J Med Chem. 1999. PMID: 10425099

5

Synthesis of derivatives of (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) modified at the 1-aromatic moiety as novel NMDA receptor antagonists: the aromatic group is essential for the activity.

Kazuta Y, Tsujita R, Yamashita K, Uchino S, Kohsaka S, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: shuto s. Bioorg Med Chem. 2002 Dec;10(12):3829-48. doi: 10.1016/s0968-0896(02)00346-2. Bioorg Med Chem. 2002. PMID: 12413836

6

Synthesis of the cyclic and acyclic acetal derivatives of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, a potent antitumor nucleoside. Design of prodrugs to be selectively activated in tumor tissues via the bio-reduction-hydrolysis mechanism.

Nomura M, Shuto S, Matsuda A. Nomura M, et al. Among authors: shuto s. Bioorg Med Chem. 2003 May 29;11(11):2453-61. doi: 10.1016/s0968-0896(03)00104-4. Bioorg Med Chem. 2003. PMID: 12735992

7

A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.

Terauchi M, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Trusselle M, Potter BV, Matsuda A, Shuto S. Terauchi M, et al. Among authors: shuto s. J Med Chem. 2006 Mar 23;49(6):1900-9. doi: 10.1021/jm051039n. J Med Chem. 2006. PMID: 16539376

8

Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.

Mochizuki T, Kondo Y, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Potter BV, Matsuda A, Shuto S. Mochizuki T, et al. Among authors: shuto s. J Med Chem. 2006 Sep 21;49(19):5750-8. doi: 10.1021/jm060310d. J Med Chem. 2006. PMID: 16970399

9

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

Kobayashi T, Watanabe M, Yoshida A, Yamada S, Ito M, Abe H, Ito Y, Arisawa M, Shuto S. Kobayashi T, et al. Among authors: shuto s. Bioorg Med Chem. 2010 Feb;18(3):1076-82. doi: 10.1016/j.bmc.2009.12.046. Epub 2009 Dec 23. Bioorg Med Chem. 2010. PMID: 20045649

10

Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine.

Watanabe M, Yamaguchi K, Tang W, Yoshida K, Silverman RB, Arisawa M, Shuto S. Watanabe M, et al. Among authors: shuto s. Bioorg Med Chem. 2011 Oct 15;19(20):5984-8. doi: 10.1016/j.bmc.2011.08.049. Epub 2011 Aug 27. Bioorg Med Chem. 2011. PMID: 21917467

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