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Deleterious mtDNA mutations are common in mature oocytes.
Ma H, Hayama T, Van Dyken C, Darby H, Koski A, Lee Y, Gutierrez NM, Yamada S, Li Y, Andrews M, Ahmed R, Liang D, Gonmanee T, Kang E, Nasser M, Kempton B, Brigande J, McGill TJ, Terzic A, Amato P, Mitalipov S. Ma H, et al. Among authors: amato p. Biol Reprod. 2020 Mar 13;102(3):607-619. doi: 10.1093/biolre/ioz202. Biol Reprod. 2020. PMID: 31621839 Free PMC article.
Metabolic rescue in pluripotent cells from patients with mtDNA disease.
Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S. Ma H, et al. Among authors: amato p. Nature. 2015 Aug 13;524(7564):234-8. doi: 10.1038/nature14546. Epub 2015 Jul 15. Nature. 2015. PMID: 26176921
Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs.
Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, Jensen J, Battaglia D, Lee D, Wu D, Terzic A, Wolf DP, Huang T, Mitalipov S. Kang E, et al. Among authors: amato p. Cell Stem Cell. 2016 May 5;18(5):625-36. doi: 10.1016/j.stem.2016.02.005. Epub 2016 Apr 14. Cell Stem Cell. 2016. PMID: 27151456 Free article.
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Kang E, et al. Among authors: amato p. Nature. 2016 Dec 8;540(7632):270-275. doi: 10.1038/nature20592. Epub 2016 Nov 30. Nature. 2016. PMID: 27919073
Germline transmission of donor, maternal and paternal mtDNA in primates.
Ma H, Van Dyken C, Darby H, Mikhalchenko A, Marti-Gutierrez N, Koski A, Liang D, Li Y, Tippner-Hedges R, Kang E, Lee Y, Sidener H, Ramsey C, Hodge T, Amato P, Mitalipov S. Ma H, et al. Among authors: amato p. Hum Reprod. 2021 Jan 25;36(2):493-505. doi: 10.1093/humrep/deaa308. Hum Reprod. 2021. PMID: 33289786 Free PMC article.
Haploidy in somatic cells is induced by mature oocytes in mice.
Lee Y, Trout A, Marti-Gutierrez N, Kang S, Xie P, Mikhalchenko A, Kim B, Choi J, So S, Han J, Xu J, Koski A, Ma H, Yoon JD, Van Dyken C, Darby H, Liang D, Li Y, Tippner-Hedges R, Xu F, Amato P, Palermo GD, Mitalipov S, Kang E. Lee Y, et al. Among authors: amato p. Commun Biol. 2022 Jan 25;5(1):95. doi: 10.1038/s42003-022-03040-5. Commun Biol. 2022. PMID: 35079104 Free PMC article.
Towards germline gene therapy of inherited mitochondrial diseases.
Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S. Tachibana M, et al. Among authors: amato p. Nature. 2013 Jan 31;493(7434):627-31. doi: 10.1038/nature11647. Epub 2012 Oct 24. Nature. 2013. PMID: 23103867 Free PMC article.
Human embryonic stem cells derived by somatic cell nuclear transfer.
Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S. Tachibana M, et al. Among authors: amato p. Cell. 2013 Jun 6;153(6):1228-38. doi: 10.1016/j.cell.2013.05.006. Epub 2013 May 15. Cell. 2013. PMID: 23683578 Free PMC article.
226 results