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Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.
Fujimoto J, Kurasawa O, Takagi T, Liu X, Banno H, Kojima T, Asano Y, Nakamura A, Nambu T, Hata A, Ishii T, Sameshima T, Debori Y, Miyamoto M, Klein MG, Tjhen R, Sang BC, Levin I, Lane SW, Snell GP, Li K, Kefala G, Hoffman ID, Ding SC, Cary DR, Mizojiri R. Fujimoto J, et al. Among authors: nakamura a. ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503. doi: 10.1021/acsmedchemlett.9b00400. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620240 Free PMC article.
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
Okaniwa M, Hirose M, Arita T, Yabuki M, Nakamura A, Takagi T, Kawamoto T, Uchiyama N, Sumita A, Tsutsumi S, Tottori T, Inui Y, Sang BC, Yano J, Aertgeerts K, Yoshida S, Ishikawa T. Okaniwa M, et al. Among authors: nakamura a. J Med Chem. 2013 Aug 22;56(16):6478-94. doi: 10.1021/jm400778d. Epub 2013 Aug 1. J Med Chem. 2013. PMID: 23906342
Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.
Nakamura A, Nambu T, Ebara S, Hasegawa Y, Toyoshima K, Tsuchiya Y, Tomita D, Fujimoto J, Kurasawa O, Takahara C, Ando A, Nishigaki R, Satomi Y, Hata A, Hara T. Nakamura A, et al. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7776-E7785. doi: 10.1073/pnas.1805523115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061420 Free PMC article.
A new role of GCN2 in the nucleolus.
Nakamura A, Kimura H. Nakamura A, et al. Biochem Biophys Res Commun. 2017 Apr 1;485(2):484-491. doi: 10.1016/j.bbrc.2017.02.038. Epub 2017 Feb 9. Biochem Biophys Res Commun. 2017. PMID: 28189689
CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade.
Morita TY, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A. Morita TY, et al. Among authors: nakamura a. Nat Commun. 2023 Nov 18;14(1):7490. doi: 10.1038/s41467-023-43274-3. Nat Commun. 2023. PMID: 37980406 Free PMC article.
Epidemiological study of Respiratory syncytial virus infection in adults during the pandemic of COVID-19.
Asai N, Shibata Y, Yamada A, Ohashi W, Takayama M, Kawamoto Y, Miyazaki N, Sakanashi D, Ohno T, Nakamura A, Koita I, Suematsu H, Chida S, Ohta T, Kato H, Hagihara M, Hirai J, Mori N, Mikamo H. Asai N, et al. Among authors: nakamura a. J Infect Chemother. 2024 May 21:S1341-321X(24)00130-2. doi: 10.1016/j.jiac.2024.05.004. Online ahead of print. J Infect Chemother. 2024. PMID: 38782237
3,785 results