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Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
Bach J, Eastwood P, González J, Gómez E, Alonso JA, Fonquerna S, Lozoya E, Orellana A, Maldonado M, Calaf E, Albertí J, Pérez J, Andrés A, Prats N, Carreño C, Calama E, De Alba J, Calbet M, Miralpeix M, Ramis I. Bach J, et al. Among authors: gomez e. J Med Chem. 2019 Oct 24;62(20):9045-9060. doi: 10.1021/acs.jmedchem.9b00533. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31609613
Indolin-2-one p38α inhibitors II: Lead optimisation.
Eastwood P, González J, Gómez E, Caturla F, Balagué C, Orellana A, Domínguez M. Eastwood P, et al. Among authors: gomez e. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5270-3. doi: 10.1016/j.bmcl.2011.07.033. Epub 2011 Jul 19. Bioorg Med Chem Lett. 2011. PMID: 21813275
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I.
Alonso JA, Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Eastwood PR, Eichhorn P, Esteve C, Gómez E, González J, Mir M, Petit S, Roberts RS, Vidal B, Vidal L, Vilaseca P, Zanuy M. Alonso JA, et al. Among authors: gomez e. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5118-22. doi: 10.1016/j.bmcl.2014.09.005. Epub 2014 Oct 15. Bioorg Med Chem Lett. 2014. PMID: 25437504
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: lead optimization.
Alonso JA, Andrés M, Bravo M, Calbet M, Eastwood PR, Eichhorn P, Esteve C, Ferrer M, Gómez E, González J, Mir M, Moreno I, Petit S, Roberts RS, Sevilla S, Vidal B, Vidal L, Vilaseca P, Zanuy M. Alonso JA, et al. Among authors: gomez e. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5123-6. doi: 10.1016/j.bmcl.2014.08.029. Epub 2014 Aug 19. Bioorg Med Chem Lett. 2014. PMID: 25437505
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: the role of a hydrogen-bond acceptor in long receptor residence times.
Alonso JA, Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Eastwood PR, Esteve C, Ferrer M, Forns P, Gómez E, González J, Lozoya E, Mir M, Moreno I, Petit S, Roberts RS, Sevilla S, Vidal B, Vidal L, Vilaseca P. Alonso JA, et al. Among authors: gomez e. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5127-33. doi: 10.1016/j.bmcl.2014.08.028. Epub 2014 Aug 19. Bioorg Med Chem Lett. 2014. PMID: 25437506
Indolin-2-one p38α inhibitors III: bioisosteric amide replacement.
Eastwood P, González J, Gómez E, Caturla F, Aguilar N, Mir M, Aiguadé J, Matassa V, Balagué C, Orellana A, Domínguez M. Eastwood P, et al. Among authors: gomez e. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6253-7. doi: 10.1016/j.bmcl.2011.09.006. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21958544
2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists.
Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Domènech T, Eichhorn P, Ferrer M, Gómez E, Lehner MD, Moreno I, Roberts RS, Sevilla S. Andrés M, et al. Among authors: gomez e. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3349-53. doi: 10.1016/j.bmcl.2013.03.093. Epub 2013 Apr 2. Bioorg Med Chem Lett. 2013. PMID: 23601708
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Camps P, Formosa X, Galdeano C, Muñoz-Torrero D, Ramírez L, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodríguez-Franco MI, Huertas O, Dafni T, Luque FJ. Camps P, et al. Among authors: gomez e. J Med Chem. 2009 Sep 10;52(17):5365-79. doi: 10.1021/jm900859q. J Med Chem. 2009. PMID: 19663388
1,928 results