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Application of the adverse outcome pathway framework to genotoxic modes of action.
Sasaki JC, Allemang A, Bryce SM, Custer L, Dearfield KL, Dietz Y, Elhajouji A, Escobar PA, Fornace AJ Jr, Froetschl R, Galloway S, Hemmann U, Hendriks G, Li HH, Luijten M, Ouedraogo G, Peel L, Pfuhler S, Roberts DJ, Thybaud V, van Benthem J, Yauk CL, Schuler M. Sasaki JC, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2020 Jan;61(1):114-134. doi: 10.1002/em.22339. Epub 2019 Oct 31. Environ Mol Mutagen. 2020. PMID: 31603995
Follow-up actions from positive results of in vitro genetic toxicity testing.
Dearfield KL, Thybaud V, Cimino MC, Custer L, Czich A, Harvey JS, Hester S, Kim JH, Kirkland D, Levy DD, Lorge E, Moore MM, Ouédraogo-Arras G, Schuler M, Suter W, Sweder K, Tarlo K, van Benthem J, van Goethem F, Witt KL. Dearfield KL, et al. Environ Mol Mutagen. 2011 Apr;52(3):177-204. doi: 10.1002/em.20617. Epub 2010 Oct 20. Environ Mol Mutagen. 2011. PMID: 20963811 Free article. Review.
Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.
Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, Elespuru RK, Johnson GE, Kirkland DJ, LeBaron MJ, Li AP, Marchetti F, Pottenger LH, Rorije E, Tanir JY, Thybaud V, van Benthem J, Yauk CL, Zeiger E, Luijten M. Dearfield KL, et al. Environ Mol Mutagen. 2017 Jun;58(5):264-283. doi: 10.1002/em.22045. Epub 2016 Sep 21. Environ Mol Mutagen. 2017. PMID: 27650663 Review.
Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene.
Luijten M, Ball NS, Dearfield KL, Gollapudi BB, Johnson GE, Madia F, Peel L, Pfuhler S, Settivari RS, Ter Burg W, White PA, van Benthem J. Luijten M, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2020 Jan;61(1):94-113. doi: 10.1002/em.22346. Epub 2019 Nov 27. Environ Mol Mutagen. 2020. PMID: 31709603 Free PMC article. Review.
Utility of a next-generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide.
Nicolette J, Luijten M, Sasaki JC, Custer L, Embry M, Froetschl R, Johnson G, Ouedraogo G, Settivari R, Thybaud V, Dearfield KL. Nicolette J, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2021 Nov;62(9):512-525. doi: 10.1002/em.22467. Epub 2021 Nov 22. Environ Mol Mutagen. 2021. PMID: 34775645 Free PMC article. Review.
The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development.
Yauk CL, Bishop J, Dearfield KL, Douglas GR, Hales BF, Luijten M, O'Brien JM, Robaire B, Sram R, van Benthem J, Wade MG, White PA, Marchetti F. Yauk CL, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2013 Mar;54(2):79-81. doi: 10.1002/em.21757. Epub 2013 Jan 28. Environ Mol Mutagen. 2013. PMID: 23355186 No abstract available.
Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.
Gollapudi BB, Johnson GE, Hernandez LG, Pottenger LH, Dearfield KL, Jeffrey AM, Julien E, Kim JH, Lovell DP, Macgregor JT, Moore MM, van Benthem J, White PA, Zeiger E, Thybaud V. Gollapudi BB, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2013 Jan;54(1):8-18. doi: 10.1002/em.21727. Epub 2012 Sep 18. Environ Mol Mutagen. 2013. PMID: 22987251
Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.
Thybaud V, Aardema M, Clements J, Dearfield K, Galloway S, Hayashi M, Jacobson-Kram D, Kirkland D, MacGregor JT, Marzin D, Ohyama W, Schuler M, Suzuki H, Zeiger E; Expert Working Group on Hazard Identification and Risk Assessment in Relation to In Vitro Testing. Thybaud V, et al. Mutat Res. 2007 Feb 3;627(1):41-58. doi: 10.1016/j.mrgentox.2006.10.003. Epub 2006 Nov 27. Mutat Res. 2007. PMID: 17126066
Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays(☆).
Yauk CL, Aardema MJ, Benthem Jv, Bishop JB, Dearfield KL, DeMarini DM, Dubrova YE, Honma M, Lupski JR, Marchetti F, Meistrich ML, Pacchierotti F, Stewart J, Waters MD, Douglas GR. Yauk CL, et al. Among authors: dearfield kl. Mutat Res Genet Toxicol Environ Mutagen. 2015 May 1;783:36-54. doi: 10.1016/j.mrgentox.2015.01.008. Epub 2015 Jan 24. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 25953399 Free article. Review.
70 results