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Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins.
Snow DM, Riling K, Kimbler A, Espinoza Y, Wong D, Pham K, Martinez Z, Kraus CN, Conrad F, Garcia-Rodriguez C, Cobb RR, Marks JD, Tomic MT. Snow DM, et al. Among authors: tomic mt. Antimicrob Agents Chemother. 2019 Sep 9;63(12):e01270-19. doi: 10.1128/AAC.01270-19. Epub 2019 Oct 7. Antimicrob Agents Chemother. 2019. PMID: 31591130 Free PMC article.
First-in-Human Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of Single Doses of NTM-1633, a Novel Mixture of Monoclonal Antibodies against Botulinum Toxin E.
Raja SM, Guptill JT, Juel VC, Walter EB, Cohen-Wolkowiez M, Hill H, Sendra E, Hauser B, Jackson P, Tomic M, Espinoza Y, Swamy GK. Raja SM, et al. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0173221. doi: 10.1128/aac.01732-21. Epub 2022 Mar 21. Antimicrob Agents Chemother. 2022. PMID: 35311524 Free PMC article. Clinical Trial.
Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin.
Garcia-Rodriguez C, Geren IN, Lou J, Conrad F, Forsyth C, Wen W, Chakraborti S, Zao H, Manzanarez G, Smith TJ, Brown J, Tepp WH, Liu N, Wijesuriya S, Tomic MT, Johnson EA, Smith LA, Marks JD. Garcia-Rodriguez C, et al. Among authors: tomic mt. Protein Eng Des Sel. 2011 Mar;24(3):321-31. doi: 10.1093/protein/gzq111. Epub 2010 Dec 13. Protein Eng Des Sel. 2011. PMID: 21149386 Free PMC article.
Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics.
House RV, Broge TA, Suscovich TJ, Snow DM, Tomic MT, Nonet G, Bajwa K, Zhu G, Martinez Z, Hackett K, Earnhart CG, Dorsey NM, Hopkins SA, Natour DS, Davis HD, Anderson MS, Gainey MR, Cobb RR. House RV, et al. Among authors: tomic mt. PLoS One. 2022 Jun 3;17(6):e0267796. doi: 10.1371/journal.pone.0267796. eCollection 2022. PLoS One. 2022. PMID: 35657812 Free PMC article.
Antibody engineering to improve manufacturability.
Wijesuriya SD, Pongo E, Tomic M, Zhang F, Garcia-Rodriquez C, Conrad F, Farr-Jones S, Marks JD, Horwitz AH. Wijesuriya SD, et al. Protein Expr Purif. 2018 Sep;149:75-83. doi: 10.1016/j.pep.2018.04.003. Epub 2018 Apr 12. Protein Expr Purif. 2018. PMID: 29655788
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