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Page 1
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites.
Matralis AN, Malik A, Penzo M, Moreno I, Almela MJ, Camino I, Crespo B, Saadeddin A, Ghidelli-Disse S, Rueda L, Calderon F, Osborne SA, Drewes G, Böesche M, Fernández-Álvaro E, Martin Hernando JI, Baker DA. Matralis AN, et al. Among authors: fernandez alvaro e. J Med Chem. 2019 Oct 24;62(20):9217-9235. doi: 10.1021/acs.jmedchem.9b01099. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31566384 Free PMC article.
High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites.
Penzo M, de Las Heras-Dueña L, Mata-Cantero L, Diaz-Hernandez B, Vazquez-Muñiz MJ, Ghidelli-Disse S, Drewes G, Fernandez-Alvaro E, Baker DA. Penzo M, et al. Among authors: fernandez alvaro e. Sci Rep. 2019 May 7;9(1):7005. doi: 10.1038/s41598-019-42801-x. Sci Rep. 2019. PMID: 31065005 Free PMC article.
Identification of Selective Inhibitors of Plasmodium N-Myristoyltransferase by High-Throughput Screening.
Harupa A, De Las Heras L, Colmenarejo G, Lyons-Abbott S, Reers A, Caballero Hernandez I, Chung CW, Charter D, Myler PJ, Fernández-Menéndez RM, Calderón F, Palomo S, Rodríguez B, Berlanga M, Herreros-Avilés E, Staker BL, Fernández Álvaro E, Kaushansky A. Harupa A, et al. Among authors: fernandez alvaro e. J Med Chem. 2020 Jan 23;63(2):591-600. doi: 10.1021/acs.jmedchem.9b01343. Epub 2020 Jan 8. J Med Chem. 2020. PMID: 31850752
Lead Optimization of Dehydroemetine for Repositioned Use in Malaria.
Panwar P, Burusco KK, Abubaker M, Matthews H, Gutnov A, Fernández-Álvaro E, Bryce RA, Wilkinson J, Nirmalan N. Panwar P, et al. Among authors: fernandez alvaro e. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01444-19. doi: 10.1128/AAC.01444-19. Print 2020 Mar 24. Antimicrob Agents Chemother. 2020. PMID: 31964796 Free PMC article.
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp.
Fernández Álvaro E, Voong Vinh P, de Cozar C, Willé DR, Urones B, Cortés A, Price A, Tran Do Hoang N, Ha Thanh T, McCloskey M, Shaheen S, Dayao D, Martinot A, de Mercado J, Castañeda P, García-Perez A, Singa B, Pavlinac P, Walson J, Martínez-Martínez MS, Arnold SLM, Tzipori S, Ballell Pages L, Baker S. Fernández Álvaro E, et al. Elife. 2022 Mar 15;11:e69798. doi: 10.7554/eLife.69798. Elife. 2022. PMID: 35289746 Free PMC article.
Correction: The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp.
Fernández Álvaro E, Voong Vinh P, de Cozar C, Willé DR, Urones B, Cortés A, Price A, Tran Do Hoang N, Ha Thanh T, McCloskey M, Shaheen S, Dayao D, Martinot A, de Mercado J, Castañeda P, García-Perez A, Singa B, Pavlinac P, Walson J, Martínez-Martínez MS, Arnold SLM, Tzipori S, Pages LB, Baker S. Fernández Álvaro E, et al. Elife. 2022 Sep 5;11:e83117. doi: 10.7554/eLife.83117. Elife. 2022. PMID: 36063387 Free PMC article.
16 results