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Nitro/nitrosyl-ruthenium complexes are potent and selective anti-Trypanosoma cruzi agents causing autophagy and necrotic parasite death.
Bastos TM, Barbosa MI, da Silva MM, da C Júnior JW, Meira CS, Guimaraes ET, Ellena J, Moreira DR, Batista AA, Soares MB. Bastos TM, et al. Among authors: da silva mm, da c junior jw. Antimicrob Agents Chemother. 2014 Oct;58(10):6044-55. doi: 10.1128/AAC.02765-14. Epub 2014 Aug 4. Antimicrob Agents Chemother. 2014. PMID: 25092707 Free PMC article.
Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole.
Corrêa RS, da Silva MM, Graminha AE, Meira CS, Santos JA, Moreira DR, Soares MB, Von Poelhsitz G, Castellano EE, Bloch C Jr, Cominetti MR, Batista AA. Corrêa RS, et al. Among authors: da silva mm. J Inorg Biochem. 2016 Mar;156:153-63. doi: 10.1016/j.jinorgbio.2015.12.024. Epub 2016 Jan 2. J Inorg Biochem. 2016. PMID: 26795676
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.
Pires WC, Lima BAV, de Castro Pereira F, Lima AP, Mello-Andrade F, Silva HD, da Silva MM, Colina-Vegas L, Ellena J, Batista AA, de Paul Silveira-Lacerda E. Pires WC, et al. Among authors: da silva mm, silva hd. Mol Cell Biochem. 2018 Jan;438(1-2):199-217. doi: 10.1007/s11010-017-3129-3. Epub 2017 Aug 9. Mol Cell Biochem. 2018. PMID: 28795366
Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors.
de Camargo MS, De Grandis RA, da Silva MM, da Silva PB, Santoni MM, Eismann CE, Menegário AA, Cominetti MR, Zanelli CF, Pavan FR, Batista AA. de Camargo MS, et al. Among authors: da silva mm, da silva pb. Biometals. 2019 Feb;32(1):89-100. doi: 10.1007/s10534-018-0160-0. Epub 2018 Nov 30. Biometals. 2019. PMID: 30506342
Ruthenium Complexes Containing Heterocyclic Thioamidates Trigger Caspase-Mediated Apoptosis Through MAPK Signaling in Human Hepatocellular Carcinoma Cells.
Neves SP, de Carvalho NC, da Silva MM, Rodrigues ACBC, Bomfim LM, Dias RB, Sales CBS, Rocha CAG, Soares MBP, Batista AA, Bezerra DP. Neves SP, et al. Among authors: da silva mm. Front Oncol. 2019 Jul 9;9:562. doi: 10.3389/fonc.2019.00562. eCollection 2019. Front Oncol. 2019. PMID: 31338323 Free PMC article.
186 results