Chen W - Search Results

1

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer.

Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, Wang C, Chen W, Bao Q, Xu X, Jiang Z, Zhang J, You Q. Wang L, et al. Among authors: chen w. Sci Adv. 2019 Sep 18;5(9):eaax2277. doi: 10.1126/sciadv.aax2277. eCollection 2019 Sep. Sci Adv. 2019. PMID: 31555737 Free PMC article.

2

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Guo X, Yang Q, Xu J, Zhang L, Chu H, Yu P, Zhu Y, Wei J, Chen W, Zhang Y, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: chen w. Bioorg Med Chem. 2013 Nov 1;21(21):6466-76. doi: 10.1016/j.bmc.2013.08.041. Epub 2013 Aug 31. Bioorg Med Chem. 2013. PMID: 24071446

3

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).

Guo X, Ma X, Yang Q, Xu J, Huang L, Jia J, Shan J, Liu L, Chen W, Chu H, Wei J, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: chen w. Eur J Med Chem. 2014 Jun 23;81:89-94. doi: 10.1016/j.ejmech.2014.03.075. Epub 2014 Mar 28. Eur J Med Chem. 2014. PMID: 24824064

4

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Feng T, Li D, Wang H, Zhuang J, Liu F, Bao Q, Lei Y, Chen W, Zhang X, Xu X, Sun H, You Q, Guo X. Feng T, et al. Among authors: chen w. Eur J Med Chem. 2015 Nov 13;105:145-55. doi: 10.1016/j.ejmech.2015.09.013. Epub 2015 Sep 10. Eur J Med Chem. 2015. PMID: 26491978

5

Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity.

Guo X, Chen W, Sun H, You Q. Guo X, et al. Among authors: chen w. Curr Top Med Chem. 2016;16(16):1843-54. doi: 10.2174/1568026616666160315142647. Curr Top Med Chem. 2016. PMID: 26975505 Review.

6

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Li DD, Chen WL, Xu XL, Jiang F, Wang L, Xie YY, Zhang XJ, Guo XK, You QD, Sun HP. Li DD, et al. Eur J Med Chem. 2016 Aug 8;118:1-8. doi: 10.1016/j.ejmech.2016.04.032. Epub 2016 Apr 13. Eur J Med Chem. 2016. PMID: 27116709

7

G9a - An Appealing Antineoplastic Target.

Chen WL, Sun HP, Li DD, Wang ZH, You QD, Guo XK. Chen WL, et al. Curr Cancer Drug Targets. 2017;17(6):555-568. doi: 10.2174/1568009616666160512145303. Curr Cancer Drug Targets. 2017. PMID: 27174055 Review.

8

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.

Li DD, Chen WL, Wang ZH, Xie YY, Xu XL, Jiang ZY, Zhang XJ, You QD, Guo XK. Li DD, et al. Eur J Med Chem. 2016 Nov 29;124:480-489. doi: 10.1016/j.ejmech.2016.08.036. Epub 2016 Aug 20. Eur J Med Chem. 2016. PMID: 27598236

9

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction.

Zhang C, Wang HJ, Bao QC, Wang L, Guo TK, Chen WL, Xu LL, Zhou HS, Bian JL, Yang YR, Sun HP, Xu XL, You QD. Zhang C, et al. Oncotarget. 2016 Nov 8;7(45):73593-73606. doi: 10.18632/oncotarget.12435. Oncotarget. 2016. PMID: 27713154 Free PMC article.

10

Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction.

Li DD, Wang ZH, Chen WL, Xie YY, You QD, Guo XK. Li DD, et al. Bioorg Med Chem. 2016 Nov 15;24(22):6109-6118. doi: 10.1016/j.bmc.2016.09.073. Epub 2016 Oct 1. Bioorg Med Chem. 2016. PMID: 27720555

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