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Context is everything: aneuploidy in cancer.
Ben-David U, Amon A. Ben-David U, et al. Nat Rev Genet. 2020 Jan;21(1):44-62. doi: 10.1038/s41576-019-0171-x. Epub 2019 Sep 23. Nat Rev Genet. 2020. PMID: 31548659 Review.
Patient-derived xenografts undergo mouse-specific tumor evolution.
Ben-David U, Ha G, Tseng YY, Greenwald NF, Oh C, Shih J, McFarland JM, Wong B, Boehm JS, Beroukhim R, Golub TR. Ben-David U, et al. Nat Genet. 2017 Nov;49(11):1567-1575. doi: 10.1038/ng.3967. Epub 2017 Oct 9. Nat Genet. 2017. PMID: 28991255 Free PMC article.
Genetic and transcriptional evolution alters cancer cell line drug response.
Ben-David U, Siranosian B, Ha G, Tang H, Oren Y, Hinohara K, Strathdee CA, Dempster J, Lyons NJ, Burns R, Nag A, Kugener G, Cimini B, Tsvetkov P, Maruvka YE, O'Rourke R, Garrity A, Tubelli AA, Bandopadhayay P, Tsherniak A, Vazquez F, Wong B, Birger C, Ghandi M, Thorner AR, Bittker JA, Meyerson M, Getz G, Beroukhim R, Golub TR. Ben-David U, et al. Nature. 2018 Aug;560(7718):325-330. doi: 10.1038/s41586-018-0409-3. Epub 2018 Aug 8. Nature. 2018. PMID: 30089904 Free PMC article.
Cas9 activates the p53 pathway and selects for p53-inactivating mutations.
Enache OM, Rendo V, Abdusamad M, Lam D, Davison D, Pal S, Currimjee N, Hess J, Pantel S, Nag A, Thorner AR, Doench JG, Vazquez F, Beroukhim R, Golub TR, Ben-David U. Enache OM, et al. Nat Genet. 2020 Jul;52(7):662-668. doi: 10.1038/s41588-020-0623-4. Epub 2020 May 18. Nat Genet. 2020. PMID: 32424350 Free PMC article.
Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.
Replogle JM, Zhou W, Amaro AE, McFarland JM, Villalobos-Ortiz M, Ryan J, Letai A, Yilmaz O, Sheltzer J, Lippard SJ, Ben-David U, Amon A. Replogle JM, et al. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30566-30576. doi: 10.1073/pnas.2009506117. Epub 2020 Nov 17. Proc Natl Acad Sci U S A. 2020. PMID: 33203674 Free PMC article.
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Bernhard SV, Kazachkova M, Tang H, Ippolito MR, Laue K, Zerbib J, Malaby HLH, Jones A, Stautmeister LM, Bockaj I, Wardenaar R, Lyons N, Nagaraja A, Bass AJ, Spierings DCJ, Foijer F, Beroukhim R, Santaguida S, Golub TR, Stumpff J, Storchová Z, Ben-David U. Cohen-Sharir Y, et al. Nature. 2021 Feb;590(7846):486-491. doi: 10.1038/s41586-020-03114-6. Epub 2021 Jan 27. Nature. 2021. PMID: 33505028 Free PMC article.
63 results