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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20760-20769. doi: 10.1073/pnas.1903216116. Epub 2019 Sep 23.
Proc Natl Acad Sci U S A. 2019.
PMID: 31548371
Free PMC article.
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.
Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL.
Collier TJ, et al. Among authors: stirtz gl.
Neurobiol Dis. 2017 Oct;106:191-204. doi: 10.1016/j.nbd.2017.07.007. Epub 2017 Jul 12.
Neurobiol Dis. 2017.
PMID: 28711409
Free PMC article.
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