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Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery.
Expert Opin Drug Discov. 2019 Dec;14(12):1313-1327. doi: 10.1080/17460441.2019.1660642. Epub 2019 Sep 20.
Expert Opin Drug Discov. 2019.
PMID: 31538500
Review.
Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo.
Soars MG, Grime K, Sproston JL, Webborn PJ, Riley RJ.
Soars MG, et al. Among authors: sproston jl.
Drug Metab Dispos. 2007 Jun;35(6):859-65. doi: 10.1124/dmd.106.014464. Epub 2007 Mar 7.
Drug Metab Dispos. 2007.
PMID: 17344337
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Application of an in vitro OAT assay in drug design and optimization of renal clearance.
Soars MG, Barton P, Elkin LL, Mosure KW, Sproston JL, Riley RJ.
Soars MG, et al. Among authors: sproston jl.
Xenobiotica. 2014 Jul;44(7):657-65. doi: 10.3109/00498254.2013.879625. Epub 2014 Jan 13.
Xenobiotica. 2014.
PMID: 24417751
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[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
Liu L, Johnson PD, Prime ME, Khetarpal V, Lee MR, Brown CJ, Chen X, Clark-Frew D, Coe S, Conlon M, Davis R, Ensor S, Esposito S, Moren AF, Gai X, Green S, Greenaway C, Haber J, Halldin C, Hayes S, Herbst T, Herrmann F, Heßmann M, Hsai MM, Kotey A, Mangette JE, Mills MR, Monteagudo E, Nag S, Nibbio M, Orsatti L, Schaertl S, Scheich C, Sproston J, Stepanov V, Varnäs K, Varrone A, Wityak J, Mrzljak L, Munoz-Sanjuan I, Bard JA, Dominguez C.
Liu L, et al.
J Med Chem. 2021 Aug 26;64(16):12003-12021. doi: 10.1021/acs.jmedchem.1c00667. Epub 2021 Aug 5.
J Med Chem. 2021.
PMID: 34351166
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Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
Liu L, Prime ME, Lee MR, Khetarpal V, Brown CJ, Johnson PD, Miranda-Azpiazu P, Chen X, Clark-Frew D, Coe S, Davis R, Dickie A, Ebneth A, Esposito S, Gadouleau E, Gai X, Galan S, Green S, Greenaway C, Giles P, Halldin C, Hayes S, Herbst T, Herrmann F, Heßmann M, Jia Z, Kiselyov A, Kotey A, Krulle T, Mangette JE, Marston RW, Menta S, Mills MR, Monteagudo E, Nag S, Nibbio M, Orsatti L, Schaertl S, Scheich C, Sproston J, Stepanov V, Svedberg M, Takano A, Taylor M, Thomas W, Toth M, Vaidya D, Vanräs K, Weddell D, Wigginton I, Wityak J, Mrzljak L, Munoz-Sanjuan I, Bard JA, Dominguez C.
Liu L, et al.
J Med Chem. 2020 Aug 13;63(15):8608-8633. doi: 10.1021/acs.jmedchem.0c00955. Epub 2020 Jul 30.
J Med Chem. 2020.
PMID: 32662649
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The Performance of an Electrorheological Fluid in Dynamic Squeeze Flow: The Influence of Solid Phase Size.
El Wahed AK, Sproston JL, Stanway R.
El Wahed AK, et al. Among authors: sproston jl.
J Colloid Interface Sci. 1999 Mar 15;211(2):264-280. doi: 10.1006/jcis.1998.5972.
J Colloid Interface Sci. 1999.
PMID: 10049543
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