Peach ML - Search Results

1

Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein.

Byun JS, Park S, Yi DI, Shin JH, Hernandez SG, Hewitt SM, Nicklaus MC, Peach ML, Guasch L, Tang B, Wakefield LM, Yan T, Caban A, Jones A, Kabbout M, Vohra N, Nápoles AM, Singhal S, Yancey R, De Siervi A, Gardner K. Byun JS, et al. Among authors: peach ml. Cell Death Dis. 2019 Sep 18;10(10):689. doi: 10.1038/s41419-019-1892-7. Cell Death Dis. 2019. PMID: 31534138 Free PMC article.

2

Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain.

Li P, Peach ML, Zhang M, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: peach ml. Bioorg Med Chem Lett. 2003 Mar 10;13(5):895-9. doi: 10.1016/s0960-894x(03)00015-5. Bioorg Med Chem Lett. 2003. PMID: 12617916

3

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: peach ml. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

4

Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.

Li P, Zhang M, Long YQ, Peach ML, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: peach ml. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2173-7. doi: 10.1016/s0960-894x(03)00385-8. Bioorg Med Chem Lett. 2003. PMID: 12798329

5

Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity.

Li P, Zhang M, Peach ML, Zhang X, Liu H, Nicklaus M, Yang D, Roller PP. Li P, et al. Among authors: peach ml. Biochem Biophys Res Commun. 2003 Aug 8;307(4):1038-44. doi: 10.1016/s0006-291x(03)01291-9. Biochem Biophys Res Commun. 2003. PMID: 12878216

6

Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: peach ml. J Med Chem. 2004 Sep 23;47(20):4858-64. doi: 10.1021/jm049723+. J Med Chem. 2004. PMID: 15369389

7

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: peach ml. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

8

Evidence that sequence homologous region in LRAT-like proteins possesses anti-proliferative activity and DNA binding properties: translational implications and mechanism of action.

Simmons DP, Peach ML, Friedman JR, Green MM, Nicklaus MC, De Luca LM. Simmons DP, et al. Among authors: peach ml. Carcinogenesis. 2006 Apr;27(4):693-707. doi: 10.1093/carcin/bgi235. Epub 2005 Oct 18. Carcinogenesis. 2006. PMID: 16234259

9

Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening.

Peach ML, Tan N, Choyke SJ, Giubellino A, Athauda G, Burke TR Jr, Nicklaus MC, Bottaro DP. Peach ML, et al. J Med Chem. 2009 Feb 26;52(4):943-51. doi: 10.1021/jm800791f. J Med Chem. 2009. PMID: 19199650 Free PMC article.

10

Combining docking with pharmacophore filtering for improved virtual screening.

Peach ML, Nicklaus MC. Peach ML, et al. J Cheminform. 2009 May 20;1(1):6. doi: 10.1186/1758-2946-1-6. J Cheminform. 2009. PMID: 20298524 Free PMC article.

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