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Identification of Cys385 in the isolated kinase insertion domain of heme-regulated eIF2 alpha kinase (HRI) as the heme axial ligand by site-directed mutagenesis and spectral characterization.
Hirai K, Martinkova M, Igarashi J, Saiful I, Yamauchi S, El-Mashtoly S, Kitagawa T, Shimizu T. Hirai K, et al. Among authors: martinkova m. J Inorg Biochem. 2007 Aug;101(8):1172-9. doi: 10.1016/j.jinorgbio.2007.05.004. Epub 2007 May 24. J Inorg Biochem. 2007. PMID: 17597215
Elucidation of the heme binding site of heme-regulated eukaryotic initiation factor 2alpha kinase and the role of the regulatory motif in heme sensing by spectroscopic and catalytic studies of mutant proteins.
Igarashi J, Murase M, Iizuka A, Pichierri F, Martinkova M, Shimizu T. Igarashi J, et al. Among authors: martinkova m. J Biol Chem. 2008 Jul 4;283(27):18782-91. doi: 10.1074/jbc.M801400200. Epub 2008 May 1. J Biol Chem. 2008. PMID: 18450746 Free article.
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA.
Stiborová M, Naiman K, Martínková M, Martínek V, Svobodová M, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: martinkova m. Interdiscip Toxicol. 2009 Mar;2(1):24-7. doi: 10.2478/v10102-009-0004-4. Interdiscip Toxicol. 2009. PMID: 21217841 Free PMC article.
Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.
Naiman K, Dračínská H, Dračínský M, Martínková M, Martínek V, Hodek P, Stícha M, Frei E, Stiborová M. Naiman K, et al. Among authors: martinkova m. Interdiscip Toxicol. 2008 Dec;1(3-4):218-24. doi: 10.2478/v10102-010-0045-8. Interdiscip Toxicol. 2008. PMID: 21218119 Free PMC article.
71 results