Safi H - Search Results

1

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance.

Safi H, Gopal P, Lingaraju S, Ma S, Levine C, Dartois V, Yee M, Li L, Blanc L, Ho Liang HP, Husain S, Hoque M, Soteropoulos P, Rustad T, Sherman DR, Dick T, Alland D. Safi H, et al. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19665-19674. doi: 10.1073/pnas.1907631116. Epub 2019 Sep 5. Proc Natl Acad Sci U S A. 2019. PMID: 31488707 Free PMC article.

2

Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.

Hazbón MH, Bobadilla del Valle M, Guerrero MI, Varma-Basil M, Filliol I, Cavatore M, Colangeli R, Safi H, Billman-Jacobe H, Lavender C, Fyfe J, García-García L, Davidow A, Brimacombe M, León CI, Porras T, Bose M, Chaves F, Eisenach KD, Sifuentes-Osornio J, Ponce de León A, Cave MD, Alland D. Hazbón MH, et al. Among authors: safi h. Antimicrob Agents Chemother. 2005 Sep;49(9):3794-802. doi: 10.1128/AAC.49.9.3794-3802.2005. Antimicrob Agents Chemother. 2005. PMID: 16127055 Free PMC article.

3

Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.

Colangeli R, Helb D, Vilchèze C, Hazbón MH, Lee CG, Safi H, Sayers B, Sardone I, Jones MB, Fleischmann RD, Peterson SN, Jacobs WR Jr, Alland D. Colangeli R, et al. Among authors: safi h. PLoS Pathog. 2007 Jun;3(6):e87. doi: 10.1371/journal.ppat.0030087. PLoS Pathog. 2007. PMID: 17590082 Free PMC article.

4

Transfer of embB codon 306 mutations into clinical Mycobacterium tuberculosis strains alters susceptibility to ethambutol, isoniazid, and rifampin.

Safi H, Sayers B, Hazbón MH, Alland D. Safi H, et al. Antimicrob Agents Chemother. 2008 Jun;52(6):2027-34. doi: 10.1128/AAC.01486-07. Epub 2008 Mar 31. Antimicrob Agents Chemother. 2008. PMID: 18378710 Free PMC article.

5

Rifampin resistance, Beijing-W clade-single nucleotide polymorphism cluster group 2 phylogeny, and the Rv2629 191-C allele in Mycobacterium tuberculosis strains.

Chakravorty S, Aladegbami B, Motiwala AS, Dai Y, Safi H, Brimacombe M, Helb D, Alland D. Chakravorty S, et al. Among authors: safi h. J Clin Microbiol. 2008 Aug;46(8):2555-60. doi: 10.1128/JCM.00666-08. Epub 2008 Jun 11. J Clin Microbiol. 2008. PMID: 18550732 Free PMC article.

6

Allelic exchange and mutant selection demonstrate that common clinical embCAB gene mutations only modestly increase resistance to ethambutol in Mycobacterium tuberculosis.

Safi H, Fleischmann RD, Peterson SN, Jones MB, Jarrahi B, Alland D. Safi H, et al. Antimicrob Agents Chemother. 2010 Jan;54(1):103-8. doi: 10.1128/AAC.01288-09. Epub 2009 Oct 12. Antimicrob Agents Chemother. 2010. PMID: 19822701 Free PMC article.

7

Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology.

Helb D, Jones M, Story E, Boehme C, Wallace E, Ho K, Kop J, Owens MR, Rodgers R, Banada P, Safi H, Blakemore R, Lan NT, Jones-López EC, Levi M, Burday M, Ayakaka I, Mugerwa RD, McMillan B, Winn-Deen E, Christel L, Dailey P, Perkins MD, Persing DH, Alland D. Helb D, et al. Among authors: safi h. J Clin Microbiol. 2010 Jan;48(1):229-37. doi: 10.1128/JCM.01463-09. Epub 2009 Oct 28. J Clin Microbiol. 2010. PMID: 19864480 Free PMC article.

8

Rapid, high-throughput detection of rifampin resistance and heteroresistance in Mycobacterium tuberculosis by use of sloppy molecular beacon melting temperature coding.

Chakravorty S, Kothari H, Aladegbami B, Cho EJ, Lee JS, Roh SS, Kim H, Kwak H, Lee EG, Hwang SH, Banada PP, Safi H, Via LE, Cho SN, Barry CE 3rd, Alland D. Chakravorty S, et al. Among authors: safi h. J Clin Microbiol. 2012 Jul;50(7):2194-202. doi: 10.1128/JCM.00143-12. Epub 2012 Apr 25. J Clin Microbiol. 2012. PMID: 22535987 Free PMC article.

9

Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes.

Safi H, Lingaraju S, Amin A, Kim S, Jones M, Holmes M, McNeil M, Peterson SN, Chatterjee D, Fleischmann R, Alland D. Safi H, et al. Nat Genet. 2013 Oct;45(10):1190-7. doi: 10.1038/ng.2743. Epub 2013 Sep 1. Nat Genet. 2013. PMID: 23995136 Free PMC article.

10

High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.

Lanoix JP, Tasneen R, O'Brien P, Sarathy J, Safi H, Pinn M, Alland D, Dartois V, Nuermberger E. Lanoix JP, et al. Among authors: safi h. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4197-205. doi: 10.1128/AAC.03085-15. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27139472 Free PMC article.

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