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A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.
Borsari C, Rageot D, Dall'Asen A, Bohnacker T, Melone A, Sele AM, Jackson E, Langlois JB, Beaufils F, Hebeisen P, Fabbro D, Hillmann P, Wymann MP. Borsari C, et al. Among authors: langlois jb. J Med Chem. 2019 Sep 26;62(18):8609-8630. doi: 10.1021/acs.jmedchem.9b00972. Epub 2019 Sep 11. J Med Chem. 2019. PMID: 31465220 Free article.
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders.
Rageot D, Bohnacker T, Melone A, Langlois JB, Borsari C, Hillmann P, Sele AM, Beaufils F, Zvelebil M, Hebeisen P, Löscher W, Burke J, Fabbro D, Wymann MP. Rageot D, et al. Among authors: langlois jb. J Med Chem. 2018 Nov 21;61(22):10084-10105. doi: 10.1021/acs.jmedchem.8b01262. Epub 2018 Nov 14. J Med Chem. 2018. PMID: 30359003 Free article.
Surface modification effect on contrast agent efficiency for X-ray based spectral photon-counting scanner/luminescence imaging: from fundamental study to in vivo proof of concept.
Cuau L, Akl P, Gautheron A, Houmeau A, Chaput F, Yaromina A, Dubois L, Lambin P, Karpati S, Parola S, Rezaeifar B, Langlois JB, Si-Mohamed SA, Montcel B, Douek P, Lerouge F. Cuau L, et al. Among authors: langlois jb. Nanoscale. 2024 Feb 8;16(6):2931-2944. doi: 10.1039/d3nr03710j. Nanoscale. 2024. PMID: 38230699
The PREMISE database of 20 Macaca fascicularis PET/MRI brain images available for research.
Chalet L, Debatisse J, Wateau O, Boutelier T, Wiart M, Costes N, Mérida I, Redouté J, Langlois JB, Lancelot S, Léon C, Cho TH, Mechtouff L, Eker OF, Nighoghossian N, Canet-Soulas E, Becker G. Chalet L, et al. Among authors: langlois jb. Lab Anim (NY). 2024 Jan;53(1):13-17. doi: 10.1038/s41684-023-01289-9. Epub 2023 Nov 23. Lab Anim (NY). 2024. PMID: 37996697 Free PMC article.
Gadolinium K-edge angiography with a spectral photon counting CT in atherosclerotic rabbits.
Boccalini S, Dessouky R, Rodesch PA, Lacombe H, Yagil Y, Lahoud E, Erhard K, Brendel B, Coulon P, Langlois JB, Chaput F, Parola S, Boussel L, Lerouge F, Si-Mohamed S, Douek PC. Boccalini S, et al. Among authors: langlois jb. Diagn Interv Imaging. 2023 Oct;104(10):490-499. doi: 10.1016/j.diii.2023.05.002. Epub 2023 May 27. Diagn Interv Imaging. 2023. PMID: 37248095
Author Correction: A consensus protocol for functional connectivity analysis in the rat brain.
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, Blockx I, Bortel A, Broadwater M, Cardoso BM, Célestine M, Chavez-Negrete JE, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes FF, Fowler CF, Fuentes-Ibañez A, Garin CM, Gelderman E, Golden CEM, Guo CCG, Henckens MJAG, Hennessy LA, Herman P, Hofwijks N, Horien C, Ionescu TM, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee SH, Lillywhite A, Liu Y, Liu YY, López-Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan MJ, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens DMP, Nava-Gomez LJ, Nonaka H, Ortiz JJ, Paasonen J, Peeters LM, Pereira M, Perez PD, Pompilus M, Prior M, Rakhmatullin R, Reimann HM, Reinwald J, Del Rio RT, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten TJ, Ryoke R, Sack M, Salvan P, Sanganahalli BG, Schroeter A, Seewoo BJ, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith JAB, Smith C, Sobczak F, Stenroos PJ, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García ME, Tudela R, van den Berg M, van der Marel K, … See abstract for full author list ➔ Grandjean J, et al. Among authors: langlois jb. Nat Neurosci. 2023 Jun;26(6):1127-1128. doi: 10.1038/s41593-023-01328-1. Nat Neurosci. 2023. PMID: 37072562 No abstract available.
Spatio-Temporal Characterization of Brain Inflammation in a Non-human Primate Stroke Model Mimicking Endovascular Thrombectomy.
Becker G, Debatisse J, Rivière M, Crola Da Silva C, Beaudoin-Gobert M, Eker O, Wateau O, Cho TH, Wiart M, Tremblay L, Costes N, Mérida I, Redouté J, Léon C, Langlois JB, Le Bars D, Lancelot S, Nighoghossian N, Mechtouff L, Canet-Soulas E. Becker G, et al. Among authors: langlois jb. Neurotherapeutics. 2023 Apr;20(3):789-802. doi: 10.1007/s13311-023-01368-2. Epub 2023 Mar 28. Neurotherapeutics. 2023. PMID: 36976495 Free PMC article. Review.
A consensus protocol for functional connectivity analysis in the rat brain.
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, Blockx I, Bortel A, Broadwater M, Cardoso BM, Célestine M, Chavez-Negrete JE, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes FF, Fowler CF, Fuentes-Ibañez A, Garin CM, Gelderman E, Golden CEM, Guo CCG, Henckens MJAG, Hennessy LA, Herman P, Hofwijks N, Horien C, Ionescu TM, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee SH, Lillywhite A, Liu Y, Liu YY, López-Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan MJ, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens DMP, Nava-Gomez LJ, Nonaka H, Ortiz JJ, Paasonen J, Peeters LM, Pereira M, Perez PD, Pompilus M, Prior M, Rakhmatullin R, Reimann HM, Reinwald J, Del Rio RT, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten TJ, Ryoke R, Sack M, Salvan P, Sanganahalli BG, Schroeter A, Seewoo BJ, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith JAB, Smith C, Sobczak F, Stenroos PJ, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García ME, Tudela R, van den Berg M, van der Marel K, … See abstract for full author list ➔ Grandjean J, et al. Among authors: langlois jb. Nat Neurosci. 2023 Apr;26(4):673-681. doi: 10.1038/s41593-023-01286-8. Epub 2023 Mar 27. Nat Neurosci. 2023. PMID: 36973511 Free PMC article.
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