Leppänen J - Search Results

1

Green and Efficient Esterification Method Using Dried Dowex H⁺/NaI Approach.

Turhanen PA, Leppänen J, Vepsäläinen JJ. Turhanen PA, et al. Among authors: leppanen j. ACS Omega. 2019 May 22;4(5):8974-8984. doi: 10.1021/acsomega.9b00790. eCollection 2019 May 31. ACS Omega. 2019. PMID: 31459986 Free PMC article.

2

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

Huttunen KM, Leppänen J, Vepsäläinen J, Sirviö J, Laine K, Rautio J. Huttunen KM, et al. Among authors: leppanen j. J Pharm Sci. 2012 Aug;101(8):2854-60. doi: 10.1002/jps.23221. Epub 2012 May 30. J Pharm Sci. 2012. PMID: 22648910

3

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin.

Huttunen KM, Leppänen J, Laine K, Vepsäläinen J, Rautio J. Huttunen KM, et al. Among authors: leppanen j. Eur J Pharm Sci. 2013 Jul 16;49(4):624-8. doi: 10.1016/j.ejps.2013.05.023. Epub 2013 Jun 1. Eur J Pharm Sci. 2013. PMID: 23732628

4

Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality.

Huttunen KM, Mähönen N, Leppänen J, Vepsäläinen J, Juvonen RO, Raunio H, Kumpulainen H, Järvinen T, Rautio J. Huttunen KM, et al. Among authors: leppanen j. Pharm Res. 2007 Apr;24(4):679-87. doi: 10.1007/s11095-006-9187-y. Epub 2007 Feb 15. Pharm Res. 2007. PMID: 17372695

5

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol.

Kumpulainen H, Järvinen T, Mannila A, Leppänen J, Nevalainen T, Mäntylä A, Vepsäläinen J, Rautio J. Kumpulainen H, et al. Among authors: leppanen j. Eur J Pharm Sci. 2008 Jul 3;34(2-3):110-7. doi: 10.1016/j.ejps.2008.02.121. Epub 2008 Mar 2. Eur J Pharm Sci. 2008. PMID: 18403185

6

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography.

Huttunen KM, Rautio J, Leppänen J, Vepsäläinen J, Keski-Rahkonen P. Huttunen KM, et al. Among authors: leppanen j. J Pharm Biomed Anal. 2009 Oct 15;50(3):469-74. doi: 10.1016/j.jpba.2009.04.033. Epub 2009 May 7. J Pharm Biomed Anal. 2009. PMID: 19481899

7

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J. Huttunen KM, et al. Among authors: leppanen j. J Med Chem. 2009 Jul 23;52(14):4142-8. doi: 10.1021/jm900274q. J Med Chem. 2009. PMID: 19522462

8

Synthesis of a water-soluble prodrug of entacapone.

Leppänen J, Huuskonen J, Savolainen J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Järvinen T. Leppänen J, et al. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1967-9. doi: 10.1016/s0960-894x(00)00384-x. Bioorg Med Chem Lett. 2000. PMID: 10987428

9

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion.

Xu W, Cui P, Happonen E, Leppänen J, Liu L, Rantanen J, Majda D, Saukko A, Thapa R, Nissinen T, Tynkkynen T, Töyräs J, Fan L, Liu W, Lehto VP. Xu W, et al. Among authors: leppanen j. ACS Appl Mater Interfaces. 2020 Oct 21;12(42):47233-47244. doi: 10.1021/acsami.0c12499. Epub 2020 Oct 7. ACS Appl Mater Interfaces. 2020. PMID: 32970405

10

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion.

Ylikangas H, Peura L, Malmioja K, Leppänen J, Laine K, Poso A, Lahtela-Kakkonen M, Rautio J. Ylikangas H, et al. Among authors: leppanen j. Eur J Pharm Sci. 2013 Feb 14;48(3):523-31. doi: 10.1016/j.ejps.2012.11.014. Epub 2012 Dec 8. Eur J Pharm Sci. 2013. PMID: 23228412

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