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Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.
Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, Finkernagel F, Obert J, Lieber S, Scharfe M, Jarek M, Toth PM, Scheer F, Diederich WE, Reinartz S, Grosse R, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: diederich we. Oncogene. 2013 Oct 31;32(44):5241-52. doi: 10.1038/onc.2012.549. Epub 2012 Dec 3. Oncogene. 2013. PMID: 23208498 Free PMC article.
The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state.
Adhikary T, Wortmann A, Schumann T, Finkernagel F, Lieber S, Roth K, Toth PM, Diederich WE, Nist A, Stiewe T, Kleinesudeik L, Reinartz S, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: diederich we. Nucleic Acids Res. 2015 May 26;43(10):5033-51. doi: 10.1093/nar/gkv331. Epub 2015 Apr 30. Nucleic Acids Res. 2015. PMID: 25934804 Free PMC article.
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.
Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R. Schumann T, et al. Among authors: diederich we. Oncotarget. 2015 May 30;6(15):13416-33. doi: 10.18632/oncotarget.3826. Oncotarget. 2015. PMID: 25968567 Free PMC article.
A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.
Niu X, Brahmbhatt H, Mergenthaler P, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW. Niu X, et al. Among authors: diederich we. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5. doi: 10.1016/j.chembiol.2017.03.011. Epub 2017 Apr 6. Cell Chem Biol. 2017. PMID: 28392146 Free PMC article.
Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis.
Jelinek A, Heyder L, Daude M, Plessner M, Krippner S, Grosse R, Diederich WE, Culmsee C. Jelinek A, et al. Among authors: diederich we. Free Radic Biol Med. 2018 Mar;117:45-57. doi: 10.1016/j.freeradbiomed.2018.01.019. Epub 2018 Jan 31. Free Radic Biol Med. 2018. PMID: 29378335
55 results