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Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB. Buter J, et al. Among authors: oldfield e. Nat Chem Biol. 2019 Sep;15(9):889-899. doi: 10.1038/s41589-019-0336-0. Epub 2019 Aug 19. Nat Chem Biol. 2019. PMID: 31427817 Free PMC article.
A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.
Kim MO, Feng X, Feixas F, Zhu W, Lindert S, Bogue S, Sinko W, de Oliveira C, Rao G, Oldfield E, McCammon JA. Kim MO, et al. Among authors: oldfield e. Chem Biol Drug Des. 2015 Jun;85(6):756-69. doi: 10.1111/cbdd.12463. Epub 2014 Nov 25. Chem Biol Drug Des. 2015. PMID: 25352216 Free PMC article.
Resistance-resistant antibiotics.
Oldfield E, Feng X. Oldfield E, et al. Trends Pharmacol Sci. 2014 Dec;35(12):664-74. doi: 10.1016/j.tips.2014.10.007. Epub 2014 Nov 5. Trends Pharmacol Sci. 2014. PMID: 25458541 Free PMC article. Review.
Tuberculosis terpene targets.
Oldfield E. Oldfield E. Chem Biol. 2015 Apr 23;22(4):437-438. doi: 10.1016/j.chembiol.2015.04.004. Chem Biol. 2015. PMID: 25910241
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.
No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. No JH, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4058-63. doi: 10.1073/pnas.1118215109. Epub 2012 Mar 5. Proc Natl Acad Sci U S A. 2012. PMID: 22392982 Free PMC article.
Antiinfectives targeting enzymes and the proton motive force.
Feng X, Zhu W, Schurig-Briccio LA, Lindert S, Shoen C, Hitchings R, Li J, Wang Y, Baig N, Zhou T, Kim BK, Crick DC, Cynamon M, McCammon JA, Gennis RB, Oldfield E. Feng X, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7073-82. doi: 10.1073/pnas.1521988112. Epub 2015 Dec 7. Proc Natl Acad Sci U S A. 2015. PMID: 26644565 Free PMC article.
928 results