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Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB. Buter J, et al. Among authors: cotton rn. Nat Chem Biol. 2019 Sep;15(9):889-899. doi: 10.1038/s41589-019-0336-0. Epub 2019 Aug 19. Nat Chem Biol. 2019. PMID: 31427817 Free PMC article.
Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.
Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ. Cheng JM, et al. Among authors: cotton rn. Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18. Chemistry. 2017. PMID: 27925318 Free PMC article.
Four pathways of CD1 antigen presentation to T cells.
Moody DB, Cotton RN. Moody DB, et al. Among authors: cotton rn. Curr Opin Immunol. 2017 Jun;46:127-133. doi: 10.1016/j.coi.2017.07.013. Epub 2017 Jul 28. Curr Opin Immunol. 2017. PMID: 28756303 Free PMC article. Review.
CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
Cotton RN, Wegrecki M, Cheng TY, Chen YL, Veerapen N, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis R, Altman JD, de Jong A, Van Rhijn I, Clark RA, Besra GS, Ogg G, Rossjohn J, Moody DB. Cotton RN, et al. J Exp Med. 2021 Jul 5;218(7):e20202699. doi: 10.1084/jem.20202699. Epub 2021 May 7. J Exp Med. 2021. PMID: 33961028 Free PMC article.
Human skin is colonized by T cells that recognize CD1a independently of lipid.
Cotton RN, Cheng TY, Wegrecki M, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis RA, Altman JD, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark RA, Moody DB. Cotton RN, et al. J Clin Invest. 2021 Jan 4;131(1):e140706. doi: 10.1172/JCI140706. J Clin Invest. 2021. PMID: 33393500 Free PMC article.
13 results