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Gene Therapy for Parkinson's Disease: Preclinical Evaluation of Optimally Configured TH:CH1 Fusion for Maximal Dopamine Synthesis.
Badin RA, Binley K, Van Camp N, Jan C, Gourlay J, Robert C, Gipchtein P, Fayard A, Stewart H, Ralph GS, Lad Y, Kelleher M, Loader J, Hosomi K, Palfi S, Mitrophanous KA, Hantraye P. Badin RA, et al. Among authors: hantraye p. Mol Ther Methods Clin Dev. 2019 Jul 16;14:206-216. doi: 10.1016/j.omtm.2019.07.002. eCollection 2019 Sep 13. Mol Ther Methods Clin Dev. 2019. PMID: 31406701 Free PMC article.
Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease.
Palfi S, Gurruchaga JM, Lepetit H, Howard K, Ralph GS, Mason S, Gouello G, Domenech P, Buttery PC, Hantraye P, Tuckwell NJ, Barker RA, Mitrophanous KA. Palfi S, et al. Among authors: hantraye p. Hum Gene Ther Clin Dev. 2018 Sep;29(3):148-155. doi: 10.1089/humc.2018.081. Hum Gene Ther Clin Dev. 2018. PMID: 30156440 Free PMC article. Clinical Trial.
Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA. Palfi S, et al. Among authors: hantraye p. Lancet. 2014 Mar 29;383(9923):1138-46. doi: 10.1016/S0140-6736(13)61939-X. Epub 2014 Jan 10. Lancet. 2014. PMID: 24412048 Clinical Trial.
Three-dimensional SPACE fluid-attenuated inversion recovery at 3 T to improve subthalamic nucleus lead placement for deep brain stimulation in Parkinson's disease: from preclinical to clinical studies.
Senova S, Hosomi K, Gurruchaga JM, Gouello G, Ouerchefani N, Beaugendre Y, Lepetit H, Lefaucheur JP, Badin RA, Dauguet J, Jan C, Hantraye P, Brugières P, Palfi S. Senova S, et al. Among authors: hantraye p. J Neurosurg. 2016 Aug;125(2):472-80. doi: 10.3171/2015.7.JNS15379. Epub 2016 Jan 8. J Neurosurg. 2016. PMID: 26745490
Assessment of simplified methods for quantification of [18F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate.
Van Camp N, Balbastre Y, Herard AS, Lavisse S, Tauber C, Wimberley C, Guillermier M, Berniard A, Gipchtein P, Jan C, Badin RA, Delzescaux T, Hantraye P, Bonvento G. Van Camp N, et al. Among authors: hantraye p. J Cereb Blood Flow Metab. 2020 May;40(5):1103-1116. doi: 10.1177/0271678X19859034. Epub 2019 Jun 25. J Cereb Blood Flow Metab. 2020. PMID: 31238764 Free PMC article.
Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates.
Senova S, Poupon C, Dauguet J, Stewart HJ, Dugué GP, Jan C, Hosomi K, Ralph GS, Barnes L, Drouot X, Pouzat C, Mangin JF, Pain F, Doignon I, Aron-Badin R, Brouillet E, Boyden ES, Mitrophanous KA, Hantraye P, Palfi S. Senova S, et al. Among authors: hantraye p. Sci Rep. 2018 Feb 20;8(1):3362. doi: 10.1038/s41598-018-21486-8. Sci Rep. 2018. PMID: 29463867 Free PMC article.
Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates.
Lavisse S, Williams S, Lecourtois S, van Camp N, Guillermier M, Gipchtein P, Jan C, Goutal S, Eymin L, Valette J, Delzescaux T, Perrier AL, Hantraye P, Aron Badin R. Lavisse S, et al. Among authors: hantraye p. Neurobiol Dis. 2019 Oct;130:104484. doi: 10.1016/j.nbd.2019.104484. Epub 2019 May 24. Neurobiol Dis. 2019. PMID: 31132407
243 results