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Adaptation of host transmission cycle during Clostridium difficile speciation.
Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD. Kumar N, et al. Among authors: wren bw. Nat Genet. 2019 Sep;51(9):1315-1320. doi: 10.1038/s41588-019-0478-8. Epub 2019 Aug 12. Nat Genet. 2019. PMID: 31406348
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome.
Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, Stabler R, Thomson NR, Roberts AP, Cerdeño-Tárraga AM, Wang H, Holden MT, Wright A, Churcher C, Quail MA, Baker S, Bason N, Brooks K, Chillingworth T, Cronin A, Davis P, Dowd L, Fraser A, Feltwell T, Hance Z, Holroyd S, Jagels K, Moule S, Mungall K, Price C, Rabbinowitsch E, Sharp S, Simmonds M, Stevens K, Unwin L, Whithead S, Dupuy B, Dougan G, Barrell B, Parkhill J. Sebaihia M, et al. Among authors: wren bw. Nat Genet. 2006 Jul;38(7):779-86. doi: 10.1038/ng1830. Epub 2006 Jun 25. Nat Genet. 2006. PMID: 16804543
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.
Thomson NR, Howard S, Wren BW, Holden MT, Crossman L, Challis GL, Churcher C, Mungall K, Brooks K, Chillingworth T, Feltwell T, Abdellah Z, Hauser H, Jagels K, Maddison M, Moule S, Sanders M, Whitehead S, Quail MA, Dougan G, Parkhill J, Prentice MB. Thomson NR, et al. Among authors: wren bw. PLoS Genet. 2006 Dec 15;2(12):e206. doi: 10.1371/journal.pgen.0020206. PLoS Genet. 2006. PMID: 17173484 Free PMC article.
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts.
Lawley TD, Clare S, Walker AW, Goulding D, Stabler RA, Croucher N, Mastroeni P, Scott P, Raisen C, Mottram L, Fairweather NF, Wren BW, Parkhill J, Dougan G. Lawley TD, et al. Among authors: wren bw. Infect Immun. 2009 Sep;77(9):3661-9. doi: 10.1128/IAI.00558-09. Epub 2009 Jun 29. Infect Immun. 2009. PMID: 19564382 Free PMC article.
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium.
Stabler RA, He M, Dawson L, Martin M, Valiente E, Corton C, Lawley TD, Sebaihia M, Quail MA, Rose G, Gerding DN, Gibert M, Popoff MR, Parkhill J, Dougan G, Wren BW. Stabler RA, et al. Among authors: wren bw. Genome Biol. 2009;10(9):R102. doi: 10.1186/gb-2009-10-9-r102. Epub 2009 Sep 25. Genome Biol. 2009. PMID: 19781061 Free PMC article.
Evolutionary dynamics of Clostridium difficile over short and long time scales.
He M, Sebaihia M, Lawley TD, Stabler RA, Dawson LF, Martin MJ, Holt KE, Seth-Smith HM, Quail MA, Rance R, Brooks K, Churcher C, Harris D, Bentley SD, Burrows C, Clark L, Corton C, Murray V, Rose G, Thurston S, van Tonder A, Walker D, Wren BW, Dougan G, Parkhill J. He M, et al. Among authors: wren bw. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7527-32. doi: 10.1073/pnas.0914322107. Epub 2010 Apr 5. Proc Natl Acad Sci U S A. 2010. PMID: 20368420 Free PMC article.
Clostridium difficile using DNA microarrays.
Stabler R, Dawson L, Wren B. Stabler R, et al. Methods Mol Biol. 2010;646:149-62. doi: 10.1007/978-1-60327-365-7_10. Methods Mol Biol. 2010. PMID: 20597008
336 results