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Page 1
Adaptation of host transmission cycle during Clostridium difficile speciation.
Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD. Kumar N, et al. Among authors: harcourt k. Nat Genet. 2019 Sep;51(9):1315-1320. doi: 10.1038/s41588-019-0478-8. Epub 2019 Aug 12. Nat Genet. 2019. PMID: 31406348
Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.
Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD, Browne HP, Keane JA, Page AJ, Kumasaka N, Kane L, Mottram L, Harcourt K, Hale C, Arends MJ, Gaffney DJ; Sanger Mouse Genetics Project; Dougan G, Lawley TD. Pham TA, et al. Among authors: harcourt k. Cell Host Microbe. 2014 Oct 8;16(4):504-16. doi: 10.1016/j.chom.2014.08.017. Epub 2014 Sep 25. Cell Host Microbe. 2014. PMID: 25263220 Free PMC article.
Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa.
Okoro CK, Barquist L, Connor TR, Harris SR, Clare S, Stevens MP, Arends MJ, Hale C, Kane L, Pickard DJ, Hill J, Harcourt K, Parkhill J, Dougan G, Kingsley RA. Okoro CK, et al. Among authors: harcourt k. PLoS Negl Trop Dis. 2015 Mar 24;9(3):e0003611. doi: 10.1371/journal.pntd.0003611. eCollection 2015 Mar. PLoS Negl Trop Dis. 2015. PMID: 25803844 Free PMC article.
NBEAL2 is required for neutrophil and NK cell function and pathogen defense.
Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA, Hoenderdos K, Harcourt K, Marsden M, Abdul-Karim J, Clement M, Antrobus R, Umrania Y, Barton PR, Flint SM, Juss JK, Condliffe AM, Lyons PA, Humphreys IR, Chilvers ER, Ouwehand WH, Dougan G, Smith KG. Sowerby JM, et al. Among authors: harcourt k. J Clin Invest. 2017 Sep 1;127(9):3521-3526. doi: 10.1172/JCI91684. Epub 2017 Aug 7. J Clin Invest. 2017. PMID: 28783043 Free PMC article.
Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection.
Gimeno Brias S, Marsden M, Forbester J, Clement M, Brandt C, Harcourt K, Kane L, Chapman L, Clare S, Humphreys IR. Gimeno Brias S, et al. Among authors: harcourt k. PLoS One. 2018 May 16;13(5):e0197596. doi: 10.1371/journal.pone.0197596. eCollection 2018. PLoS One. 2018. PMID: 29768502 Free PMC article.
New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.
Mather AE, Phuong TLT, Gao Y, Clare S, Mukhopadhyay S, Goulding DA, Hoang NTD, Tuyen HT, Lan NPH, Thompson CN, Trang NHT, Carrique-Mas J, Tue NT, Campbell JI, Rabaa MA, Thanh DP, Harcourt K, Hoa NT, Trung NV, Schultsz C, Perron GG, Coia JE, Brown DJ, Okoro C, Parkhill J, Thomson NR, Chau NVV, Thwaites GE, Maskell DJ, Dougan G, Kenney LJ, Baker S. Mather AE, et al. Among authors: harcourt k. mBio. 2018 Sep 4;9(5):e01056-18. doi: 10.1128/mBio.01056-18. mBio. 2018. PMID: 30181247 Free PMC article.
FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.
Ballesteros Reviriego C, Clare S, Arends MJ, Cambridge EL, Swiatkowska A, Caetano S, Abu-Helil B, Kane L, Harcourt K, Goulding DA, Gleeson D, Ryder E, Doe B, White JK, van der Weyden L, Dougan G, Adams DJ, Speak AO. Ballesteros Reviriego C, et al. Among authors: harcourt k. PLoS One. 2019 Mar 6;14(3):e0212481. doi: 10.1371/journal.pone.0212481. eCollection 2019. PLoS One. 2019. PMID: 30840666 Free PMC article.
An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation.
Van Puyvelde S, Pickard D, Vandelannoote K, Heinz E, Barbé B, de Block T, Clare S, Coomber EL, Harcourt K, Sridhar S, Lees EA, Wheeler NE, Klemm EJ, Kuijpers L, Mbuyi Kalonji L, Phoba MF, Falay D, Ngbonda D, Lunguya O, Jacobs J, Dougan G, Deborggraeve S. Van Puyvelde S, et al. Among authors: harcourt k. Nat Commun. 2019 Sep 19;10(1):4280. doi: 10.1038/s41467-019-11844-z. Nat Commun. 2019. PMID: 31537784 Free PMC article.
59 results