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Tropism for tuft cells determines immune promotion of norovirus pathogenesis.
Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW. Wilen CB, et al. Science. 2018 Apr 13;360(6385):204-208. doi: 10.1126/science.aar3799. Science. 2018. PMID: 29650672 Free PMC article.
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.
Brestoff JR, Wilen CB, Moley JR, Li Y, Zou W, Malvin NP, Rowen MN, Saunders BT, Ma H, Mack MR, Hykes BL Jr, Balce DR, Orvedahl A, Williams JW, Rohatgi N, Wang X, McAllaster MR, Handley SA, Kim BS, Doench JG, Zinselmeyer BH, Diamond MS, Virgin HW, Gelman AE, Teitelbaum SL. Brestoff JR, et al. Among authors: wilen cb. Cell Metab. 2021 Feb 2;33(2):270-282.e8. doi: 10.1016/j.cmet.2020.11.008. Epub 2020 Dec 4. Cell Metab. 2021. PMID: 33278339 Free PMC article.
UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages.
Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. Balce DR, et al. Among authors: wilen cb. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2011763118. doi: 10.1073/pnas.2011763118. Proc Natl Acad Sci U S A. 2021. PMID: 33372156 Free PMC article.
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.
Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL Jr, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW. Lee S, et al. Among authors: wilen cb. Cell Host Microbe. 2019 Jun 12;25(6):845-857.e5. doi: 10.1016/j.chom.2019.04.005. Epub 2019 May 23. Cell Host Microbe. 2019. PMID: 31130511 Free PMC article.
The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon.
Grau KR, Zhu S, Peterson ST, Helm EW, Philip D, Phillips M, Hernandez A, Turula H, Frasse P, Graziano VR, Wilen CB, Wobus CE, Baldridge MT, Karst SM. Grau KR, et al. Among authors: wilen cb. Nat Microbiol. 2020 Jan;5(1):84-92. doi: 10.1038/s41564-019-0602-7. Epub 2019 Nov 25. Nat Microbiol. 2020. PMID: 31768030 Free PMC article.
CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus.
Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, Orchard RC, Baldridge MT, Wilen CB. Graziano VR, et al. Among authors: wilen cb. PLoS Pathog. 2020 Apr 6;16(4):e1008242. doi: 10.1371/journal.ppat.1008242. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32251490 Free PMC article.
118 results