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207 results

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Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers.
Duisters K, Ogino S, Andou T, Ito K, Akabane T, Harms A, Moerland M, Hashimoto Y, Ando A, Ohtsu Y, Wada N, Yukinaga H, Meulman J, Kobayashi H, Kobayashi N, Suzumura K, Hankemeier T. Duisters K, et al. Among authors: moerland m. Clin Pharmacol Ther. 2020 Feb;107(2):397-405. doi: 10.1002/cpt.1606. Epub 2019 Sep 23. Clin Pharmacol Ther. 2020. PMID: 31400148
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Grievink HW, Heuberger JAAC, Huang F, Chaudhary R, Birkhoff WAJ, Tonn GR, Mosesova S, Erickson R, Moerland M, Haddick PCG, Scearce-Levie K, Ho C, Groeneveld GJ. Grievink HW, et al. Among authors: moerland m. Clin Pharmacol Ther. 2020 Feb;107(2):406-414. doi: 10.1002/cpt.1615. Epub 2019 Sep 25. Clin Pharmacol Ther. 2020. PMID: 31437302 Clinical Trial.
Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.
Buters TP, Hameeteman PW, Jansen IME, van Hindevoort FC, Ten Voorde W, Florencia E, Osse M, de Kam ML, Grievink HW, Schoonakker M, Patel AA, Yona S, Gilroy DW, Lubberts E, Damman J, Feiss G, Rissmann R, Jansen MAA, Burggraaf J, Moerland M. Buters TP, et al. Among authors: moerland m. Br J Clin Pharmacol. 2022 Feb;88(2):680-690. doi: 10.1111/bcp.14999. Epub 2021 Aug 24. Br J Clin Pharmacol. 2022. PMID: 34293819 Free PMC article.
Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers.
Buters TP, Hameeteman PW, Jansen IME, van Hindevoort FC, Ten Voorde W, Grievink HW, Schoonakker M, de Kam ML, Gilroy DW, Feiss G, Rissmann R, Jansen MAA, Burggraaf J, Moerland M. Buters TP, et al. Among authors: moerland m. Clin Pharmacol Ther. 2022 Apr;111(4):964-971. doi: 10.1002/cpt.2516. Epub 2022 Jan 6. Clin Pharmacol Ther. 2022. PMID: 34935141 Free PMC article.
OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.
Saghari M, Gal P, Gilbert S, Yateman M, Porter-Brown B, Brennan N, Quaratino S, Wilson R, Grievink HW, Klaassen ES, Bergmann KR, Burggraaf J, van Doorn MBA, Powell J, Moerland M, Rissmann R. Saghari M, et al. Among authors: moerland m. Clin Pharmacol Ther. 2022 May;111(5):1121-1132. doi: 10.1002/cpt.2539. Epub 2022 Mar 1. Clin Pharmacol Ther. 2022. PMID: 35092305 Free PMC article. Clinical Trial.
Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis.
Dillingh MR, van den Blink B, Moerland M, van Dongen MG, Levi M, Kleinjan A, Wijsenbeek MS, Lupher ML Jr, Harper DM, Getsy JA, Hoogsteden HC, Burggraaf J. Dillingh MR, et al. Among authors: moerland m. Pulm Pharmacol Ther. 2013 Dec;26(6):672-6. doi: 10.1016/j.pupt.2013.01.008. Epub 2013 Feb 4. Pulm Pharmacol Ther. 2013. PMID: 23380438 Clinical Trial.
Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.
van Poelgeest EP, Hodges MR, Moerland M, Tessier Y, Levin AA, Persson R, Lindholm MW, Dumong Erichsen K, Ørum H, Cohen AF, Burggraaf J. van Poelgeest EP, et al. Among authors: moerland m. Br J Clin Pharmacol. 2015 Dec;80(6):1350-61. doi: 10.1111/bcp.12738. Epub 2015 Oct 24. Br J Clin Pharmacol. 2015. PMID: 26261033 Free PMC article. Clinical Trial.
Injection site reactions after subcutaneous oligonucleotide therapy.
van Meer L, Moerland M, Gallagher J, van Doorn MB, Prens EP, Cohen AF, Rissmann R, Burggraaf J. van Meer L, et al. Among authors: moerland m. Br J Clin Pharmacol. 2016 Aug;82(2):340-51. doi: 10.1111/bcp.12961. Epub 2016 May 31. Br J Clin Pharmacol. 2016. PMID: 27061947 Free PMC article. Review.
207 results