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Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder.
Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD Jr, Alexander P, Van QN, Moree B, Stephen AG, Weber DJ, Salafsky J, McCormick F. Donohue E, et al. Among authors: alexander p. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17290-17297. doi: 10.1073/pnas.1905516116. Epub 2019 Aug 9. Proc Natl Acad Sci U S A. 2019. PMID: 31399543 Free PMC article.
The small molecule BI-2852 induces a nonfunctional dimer of KRAS.
Tran TH, Alexander P, Dharmaiah S, Agamasu C, Nissley DV, McCormick F, Esposito D, Simanshu DK, Stephen AG, Balius TE. Tran TH, et al. Among authors: alexander p. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3363-3364. doi: 10.1073/pnas.1918164117. Epub 2020 Feb 11. Proc Natl Acad Sci U S A. 2020. PMID: 32047043 Free PMC article. No abstract available.
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.
Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG. Van QN, et al. Among authors: alexander p. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24258-24268. doi: 10.1073/pnas.2006504117. Epub 2020 Sep 10. Proc Natl Acad Sci U S A. 2020. PMID: 32913056 Free PMC article.
Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions.
Gillette WK, Esposito D, Abreu Blanco M, Alexander P, Bindu L, Bittner C, Chertov O, Frank PH, Grose C, Jones JE, Meng Z, Perkins S, Van Q, Ghirlando R, Fivash M, Nissley DV, McCormick F, Holderfield M, Stephen AG. Gillette WK, et al. Among authors: alexander p. Sci Rep. 2015 Nov 2;5:15916. doi: 10.1038/srep15916. Sci Rep. 2015. PMID: 26522388 Free PMC article.
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK. Bonsor DA, et al. Among authors: alexander p. Nat Struct Mol Biol. 2022 Oct;29(10):966-977. doi: 10.1038/s41594-022-00841-4. Epub 2022 Sep 29. Nat Struct Mol Biol. 2022. PMID: 36175670 Free PMC article.
Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum.
Senadeera SPD, Wang D, Kim CK, Smith EA, Durrant DE, Alexander PA, Wendt KL, Stephen AG, Morrison DK, Cichewicz RH, Henrich CJ, Beutler JA. Senadeera SPD, et al. Among authors: alexander pa. J Nat Prod. 2022 Jun 24;85(6):1603-1616. doi: 10.1021/acs.jnatprod.2c00240. Epub 2022 Jun 13. J Nat Prod. 2022. PMID: 35696348 Free PMC article. Review.
1,090 results