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BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells.
Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, Yuan GC, Young RA, George RE. Debruyne DN, et al. Among authors: seruggia d. Nature. 2019 Aug;572(7771):676-680. doi: 10.1038/s41586-019-1472-0. Epub 2019 Aug 7. Nature. 2019. PMID: 31391581 Free PMC article.
Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy.
Di Pilato M, Kim EY, Cadilha BL, Prüßmann JN, Nasrallah MN, Seruggia D, Usmani SM, Misale S, Zappulli V, Carrizosa E, Mani V, Ligorio M, Warner RD, Medoff BD, Marangoni F, Villani AC, Mempel TR. Di Pilato M, et al. Among authors: seruggia d. Nature. 2019 Jun;570(7759):112-116. doi: 10.1038/s41586-019-1215-2. Epub 2019 May 15. Nature. 2019. PMID: 31092922 Free PMC article.
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.
Sher F, Hossain M, Seruggia D, Schoonenberg VAC, Yao Q, Cifani P, Dassama LMK, Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver MC, Kurita R, Nakamura Y, Fujiwara Y, Wolfe SA, Pinello L, Maeda T, Kentsis A, Orkin SH, Bauer DE. Sher F, et al. Among authors: seruggia d. Nat Genet. 2019 Jul;51(7):1149-1159. doi: 10.1038/s41588-019-0453-4. Epub 2019 Jun 28. Nat Genet. 2019. PMID: 31253978 Free PMC article.
Enhancer dependence of cell-type-specific gene expression increases with developmental age.
Cai W, Huang J, Zhu Q, Li BE, Seruggia D, Zhou P, Nguyen M, Fujiwara Y, Xie H, Yang Z, Hong D, Ren P, Xu J, Pu WT, Yuan GC, Orkin SH. Cai W, et al. Among authors: seruggia d. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21450-21458. doi: 10.1073/pnas.2008672117. Epub 2020 Aug 19. Proc Natl Acad Sci U S A. 2020. PMID: 32817427 Free PMC article.
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.
Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA. Singh H, et al. Among authors: seruggia d. Genes Dev. 2022 Jan 1;36(1-2):38-52. doi: 10.1101/gad.348983.121. Epub 2021 Dec 30. Genes Dev. 2022. PMID: 34969824 Free PMC article.
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells.
Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman SR, Seruggia D, Zhang K, Fujiwara Y, Donovan KA, Zhu Q, Yang H, Nabet B, Gray NS, Mann M, Fischer ES, Adelman K, Orkin SH. Mehta S, et al. Among authors: seruggia d. Cell Chem Biol. 2022 Aug 18;29(8):1273-1287.e8. doi: 10.1016/j.chembiol.2022.06.007. Epub 2022 Jul 14. Cell Chem Biol. 2022. PMID: 35839780 Free PMC article.
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