Tomkinson NCO - Search Results

1

Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death.

Radhi OA, Davidson S, Scott F, Zeng RX, Jones DH, Tomkinson NCO, Yu J, Chan EYW. Radhi OA, et al. Among authors: tomkinson nco. J Biol Chem. 2019 Sep 27;294(39):14289-14307. doi: 10.1074/jbc.RA119.008923. Epub 2019 Aug 6. J Biol Chem. 2019. PMID: 31387948 Free PMC article.

2

Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers.

Jones DH, Bresciani S, Tellam JP, Wojno J, Cooper AW, Kennedy AR, Tomkinson NC. Jones DH, et al. Org Biomol Chem. 2016 Jan 7;14(1):172-82. doi: 10.1039/c5ob01924a. Org Biomol Chem. 2016. PMID: 26468867 Free article.

3

Stereoselective Synthesis of Alkylidene Phthalides.

Dragan A, Jones DH, Kennedy AR, Tomkinson NC. Dragan A, et al. Org Lett. 2016 Jul 1;18(13):3086-9. doi: 10.1021/acs.orglett.6b01203. Epub 2016 Jun 17. Org Lett. 2016. PMID: 27311815 Free article.

4

Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.

Jones DH, Kay ST, McLellan JA, Kennedy AR, Tomkinson NCO. Jones DH, et al. Among authors: tomkinson nco. Org Lett. 2017 Jul 7;19(13):3512-3515. doi: 10.1021/acs.orglett.7b01481. Epub 2017 Jun 16. Org Lett. 2017. PMID: 28621955 Free article.

5

Regioselective Reaction of Heterocyclic N-Oxides, an Acyl Chloride, and Cyclic Thioethers.

Frei P, Jones DH, Kay ST, McLellan JA, Johnston BF, Kennedy AR, Tomkinson NCO. Frei P, et al. Among authors: tomkinson nco. J Org Chem. 2018 Feb 2;83(3):1510-1517. doi: 10.1021/acs.joc.7b02457. Epub 2018 Jan 18. J Org Chem. 2018. PMID: 29345136 Free article.

6

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW. Pariollaud M, et al. J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30. J Clin Invest. 2018. PMID: 29533925 Free PMC article.

7

The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation.

Salaun C, Greaves J, Tomkinson NCO, Chamberlain LH. Salaun C, et al. Among authors: tomkinson nco. J Biol Chem. 2020 May 22;295(21):7501-7515. doi: 10.1074/jbc.RA120.012726. Epub 2020 Apr 21. J Biol Chem. 2020. PMID: 32317281 Free PMC article.

8

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation.

Salaun C, Takizawa H, Galindo A, Munro KR, McLellan J, Sugimoto I, Okino T, Tomkinson NCO, Chamberlain LH. Salaun C, et al. Among authors: tomkinson nco. J Biol Chem. 2022 Oct;298(10):102469. doi: 10.1016/j.jbc.2022.102469. Epub 2022 Sep 8. J Biol Chem. 2022. PMID: 36087837 Free PMC article.

9

S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.

Butler L, Locatelli C, Allagioti D, Lousa I, Lemonidis K, Tomkinson NCO, Salaun C, Chamberlain LH. Butler L, et al. Among authors: tomkinson nco. J Biol Chem. 2023 Jan;299(1):102754. doi: 10.1016/j.jbc.2022.102754. Epub 2022 Nov 25. J Biol Chem. 2023. PMID: 36442513 Free PMC article.

10

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.

Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, Chung CW, Dittmann A, Drewes G, Drewry DH, Gordon L, Grandi P, Leveridge M, Lindon M, Michon AM, Molnar J, Robson SC, Tomkinson NC, Kouzarides T, Prinjha RK, Humphreys PG. Theodoulou NH, et al. J Med Chem. 2016 Feb 25;59(4):1425-39. doi: 10.1021/acs.jmedchem.5b00256. Epub 2015 Apr 30. J Med Chem. 2016. PMID: 25856009 Free PMC article.

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