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Cytokines can counteract the inhibitory effect of MEK-i on NK-cell function.
Manzini C, Venè R, Cossu I, Gualco M, Zupo S, Dono M, Spagnolo F, Queirolo P, Moretta L, Mingari MC, Pietra G. Manzini C, et al. Among authors: pietra g. Oncotarget. 2016 Sep 20;7(38):60858-60871. doi: 10.18632/oncotarget.11504. Oncotarget. 2016. PMID: 27563819 Free PMC article.
Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor.
Balsamo M, Vermi W, Parodi M, Pietra G, Manzini C, Queirolo P, Lonardi S, Augugliaro R, Moretta A, Facchetti F, Moretta L, Mingari MC, Vitale M. Balsamo M, et al. Among authors: pietra g. Eur J Immunol. 2012 Jul;42(7):1833-42. doi: 10.1002/eji.201142179. Epub 2012 May 25. Eur J Immunol. 2012. PMID: 22585684 Free article.
The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α production.
Laurent S, Queirolo P, Boero S, Salvi S, Piccioli P, Boccardo S, Minghelli S, Morabito A, Fontana V, Pietra G, Carrega P, Ferrari N, Tosetti F, Chang LJ, Mingari MC, Ferlazzo G, Poggi A, Pistillo MP. Laurent S, et al. Among authors: pietra g. J Transl Med. 2013 May 1;11:108. doi: 10.1186/1479-5876-11-108. J Transl Med. 2013. PMID: 23634660 Free PMC article.
Human natural killer cells: news in the therapy of solid tumors and high-risk leukemias.
Pietra G, Vitale C, Pende D, Bertaina A, Moretta F, Falco M, Vacca P, Montaldo E, Cantoni C, Mingari MC, Moretta A, Locatelli F, Moretta L. Pietra G, et al. Cancer Immunol Immunother. 2016 Apr;65(4):465-76. doi: 10.1007/s00262-015-1744-y. Epub 2015 Aug 20. Cancer Immunol Immunother. 2016. PMID: 26289090 Free PMC article. Review.
Human NK cells: From surface receptors to clinical applications.
Moretta L, Pietra G, Vacca P, Pende D, Moretta F, Bertaina A, Mingari MC, Locatelli F, Moretta A. Moretta L, et al. Among authors: pietra g. Immunol Lett. 2016 Oct;178:15-9. doi: 10.1016/j.imlet.2016.05.007. Epub 2016 May 13. Immunol Lett. 2016. PMID: 27185471
279 results