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Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant.
Giorgino T, Mattioni D, Hassan A, Milani M, Mastrangelo E, Barbiroli A, Verhelle A, Gettemans J, Barzago MM, Diomede L, de Rosa M. Giorgino T, et al. Among authors: diomede l. Biochim Biophys Acta Mol Basis Dis. 2019 Mar 1;1865(3):648-660. doi: 10.1016/j.bbadis.2019.01.010. Epub 2019 Jan 6. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30625383 Free article.
A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation.
Bollati M, Diomede L, Giorgino T, Natale C, Fagnani E, Boniardi I, Barbiroli A, Alemani R, Beeg M, Gobbi M, Fakin A, Mastrangelo E, Milani M, Presciuttini G, Gabellieri E, Cioni P, de Rosa M. Bollati M, et al. Among authors: diomede l. Comput Struct Biotechnol J. 2021 Nov 19;19:6355-6365. doi: 10.1016/j.csbj.2021.11.025. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34938411 Free PMC article.
L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure.
Rizzari C, Zucchetti M, Conter V, Diomede L, Bruno A, Gavazzi L, Paganini M, Sparano P, Lo Nigro L, Aricò M, Milani M, D'Incalci M. Rizzari C, et al. Among authors: diomede l. Ann Oncol. 2000 Feb;11(2):189-93. doi: 10.1023/a:1008368916800. Ann Oncol. 2000. PMID: 10761754 Free article. Clinical Trial.
Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains.
Maritan M, Romeo M, Oberti L, Sormanni P, Tasaki M, Russo R, Ambrosetti A, Motta P, Rognoni P, Mazzini G, Barbiroli A, Palladini G, Vendruscolo M, Diomede L, Bolognesi M, Merlini G, Lavatelli F, Ricagno S. Maritan M, et al. Among authors: diomede l. J Mol Biol. 2020 Feb 14;432(4):845-860. doi: 10.1016/j.jmb.2019.12.015. Epub 2019 Dec 24. J Mol Biol. 2020. PMID: 31874151 Free article.
Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains.
Russo R, Romeo M, Schulte T, Maritan M, Oberti L, Barzago MM, Barbiroli A, Pappone C, Anastasia L, Palladini G, Diomede L, Ricagno S. Russo R, et al. Among authors: diomede l. Int J Mol Sci. 2022 Jan 16;23(2):950. doi: 10.3390/ijms23020950. Int J Mol Sci. 2022. PMID: 35055136 Free PMC article.
124 results