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Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.
Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Seegar TCM, et al. Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7. Cell. 2017. PMID: 29224781 Free PMC article.
Development of a covalent inhibitor of gut bacterial bile salt hydrolases.
Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS. Adhikari AA, et al. Among authors: seegar tcm. Nat Chem Biol. 2020 Mar;16(3):318-326. doi: 10.1038/s41589-020-0467-3. Epub 2020 Feb 10. Nat Chem Biol. 2020. PMID: 32042200 Free PMC article.
Targeted Degradation of the Oncogenic Phosphatase SHP2.
Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SC. Vemulapalli V, et al. Among authors: seegar tcm. Biochemistry. 2021 Aug 31;60(34):2593-2609. doi: 10.1021/acs.biochem.1c00377. Epub 2021 Aug 19. Biochemistry. 2021. PMID: 34411482 Free PMC article.
Structural Basis for Regulation of ESCRT-III Complexes by Lgd.
McMillan BJ, Tibbe C, Drabek AA, Seegar TCM, Blacklow SC, Klein T. McMillan BJ, et al. Among authors: seegar tcm. Cell Rep. 2017 May 30;19(9):1750-1757. doi: 10.1016/j.celrep.2017.05.026. Cell Rep. 2017. PMID: 28564595 Free PMC article.
16 results