Lander GC - Search Results

1

Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.

Puchades C, Ding B, Song A, Wiseman RL, Lander GC, Glynn SE. Puchades C, et al. Among authors: lander gc. Mol Cell. 2019 Sep 5;75(5):1073-1085.e6. doi: 10.1016/j.molcel.2019.06.016. Epub 2019 Jul 18. Mol Cell. 2019. PMID: 31327635 Free PMC article.

2

The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.

Gardner BM, Chowdhury S, Lander GC, Martin A. Gardner BM, et al. Among authors: lander gc. J Mol Biol. 2015 Mar 27;427(6 Pt B):1375-1388. doi: 10.1016/j.jmb.2015.01.019. Epub 2015 Feb 7. J Mol Biol. 2015. PMID: 25659908 Free PMC article.

3

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.

Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A. Garnham CP, et al. Among authors: lander gc. Cell. 2015 May 21;161(5):1112-1123. doi: 10.1016/j.cell.2015.04.003. Epub 2015 May 7. Cell. 2015. PMID: 25959773 Free PMC article.

4

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. Chen KC, et al. Among authors: lander gc. EMBO J. 2017 Aug 1;36(15):2296-2309. doi: 10.15252/embj.201695616. Epub 2017 Jun 27. EMBO J. 2017. PMID: 28655754 Free PMC article.

5

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC. Puchades C, et al. Among authors: lander gc. Science. 2017 Nov 3;358(6363):eaao0464. doi: 10.1126/science.aao0464. Science. 2017. PMID: 29097521 Free PMC article.

6

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.

Gardner BM, Castanzo DT, Chowdhury S, Stjepanovic G, Stefely MS, Hurley JH, Lander GC, Martin A. Gardner BM, et al. Among authors: lander gc. Nat Commun. 2018 Jan 10;9(1):135. doi: 10.1038/s41467-017-02474-4. Nat Commun. 2018. PMID: 29321502 Free PMC article.

7

Conformational ensemble of the human TRPV3 ion channel.

Zubcevic L, Herzik MA Jr, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY. Zubcevic L, et al. Among authors: lander gc. Nat Commun. 2018 Nov 14;9(1):4773. doi: 10.1038/s41467-018-07117-w. Nat Commun. 2018. PMID: 30429472 Free PMC article.

8

Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry.

Rollins MF, Chowdhury S, Carter J, Golden SM, Miettinen HM, Santiago-Frangos A, Faith D, Lawrence CM, Lander GC, Wiedenheft B. Rollins MF, et al. Among authors: lander gc. Mol Cell. 2019 Apr 4;74(1):132-142.e5. doi: 10.1016/j.molcel.2019.02.001. Epub 2019 Mar 11. Mol Cell. 2019. PMID: 30872121 Free PMC article.

9

The molecular principles governing the activity and functional diversity of AAA+ proteins.

Puchades C, Sandate CR, Lander GC. Puchades C, et al. Among authors: lander gc. Nat Rev Mol Cell Biol. 2020 Jan;21(1):43-58. doi: 10.1038/s41580-019-0183-6. Epub 2019 Nov 21. Nat Rev Mol Cell Biol. 2020. PMID: 31754261 Free PMC article. Review.

10

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.

Shin M, Puchades C, Asmita A, Puri N, Adjei E, Wiseman RL, Karzai AW, Lander GC. Shin M, et al. Among authors: lander gc. Sci Adv. 2020 May 20;6(21):eaba8404. doi: 10.1126/sciadv.aba8404. eCollection 2020 May. Sci Adv. 2020. PMID: 32490208 Free PMC article.

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