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Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation.
Ciardiello C, Leone A, Lanuti P, Roca MS, Moccia T, Minciacchi VR, Minopoli M, Gigantino V, De Cecio R, Rippa M, Petti L, Capone F, Vitagliano C, Milone MR, Pucci B, Lombardi R, Iannelli F, Di Gennaro E, Bruzzese F, Marchisio M, Carriero MV, Di Vizio D, Budillon A. Ciardiello C, et al. Among authors: minciacchi vr. J Exp Clin Cancer Res. 2019 Jul 18;38(1):317. doi: 10.1186/s13046-019-1317-6. J Exp Clin Cancer Res. 2019. PMID: 31319863 Free PMC article.
Large oncosomes mediate intercellular transfer of functional microRNA.
Morello M, Minciacchi VR, de Candia P, Yang J, Posadas E, Kim H, Griffiths D, Bhowmick N, Chung LW, Gandellini P, Freeman MR, Demichelis F, Di Vizio D. Morello M, et al. Among authors: minciacchi vr. Cell Cycle. 2013 Nov 15;12(22):3526-36. doi: 10.4161/cc.26539. Epub 2013 Sep 23. Cell Cycle. 2013. PMID: 24091630 Free PMC article.
Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles.
Minciacchi VR, You S, Spinelli C, Morley S, Zandian M, Aspuria PJ, Cavallini L, Ciardiello C, Reis Sobreiro M, Morello M, Kharmate G, Jang SC, Kim DK, Hosseini-Beheshti E, Tomlinson Guns E, Gleave M, Gho YS, Mathivanan S, Yang W, Freeman MR, Di Vizio D. Minciacchi VR, et al. Oncotarget. 2015 May 10;6(13):11327-41. doi: 10.18632/oncotarget.3598. Oncotarget. 2015. PMID: 25857301 Free PMC article.
High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients.
Conley A, Minciacchi VR, Lee DH, Knudsen BS, Karlan BY, Citrigno L, Viglietto G, Tewari M, Freeman MR, Demichelis F, Di Vizio D. Conley A, et al. Among authors: minciacchi vr. RNA Biol. 2017 Mar 4;14(3):305-316. doi: 10.1080/15476286.2016.1259061. Epub 2016 Nov 18. RNA Biol. 2017. PMID: 27858503 Free PMC article.
MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer.
Minciacchi VR, Spinelli C, Reis-Sobreiro M, Cavallini L, You S, Zandian M, Li X, Mishra R, Chiarugi P, Adam RM, Posadas EM, Viglietto G, Freeman MR, Cocucci E, Bhowmick NA, Di Vizio D. Minciacchi VR, et al. Cancer Res. 2017 May 1;77(9):2306-2317. doi: 10.1158/0008-5472.CAN-16-2942. Epub 2017 Feb 15. Cancer Res. 2017. PMID: 28202510
Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma.
Vagner T, Spinelli C, Minciacchi VR, Balaj L, Zandian M, Conley A, Zijlstra A, Freeman MR, Demichelis F, De S, Posadas EM, Tanaka H, Di Vizio D. Vagner T, et al. Among authors: minciacchi vr. J Extracell Vesicles. 2018 Aug 7;7(1):1505403. doi: 10.1080/20013078.2018.1505403. eCollection 2018. J Extracell Vesicles. 2018. PMID: 30108686 Free PMC article.
Large and small extracellular vesicles released by glioma cells in vitro and in vivo.
Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L. Yekula A, et al. Among authors: minciacchi vr. J Extracell Vesicles. 2019 Nov 27;9(1):1689784. doi: 10.1080/20013078.2019.1689784. eCollection 2020. J Extracell Vesicles. 2019. PMID: 31839905 Free PMC article.
21 results