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Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.
Sabrautzki S, Kaiser G, Przemeck GKH, Gerst F, Lorza-Gil E, Panse M, Sartorius T, Hoene M, Marschall S, Häring HU, Hrabě de Angelis M, Ullrich S. Sabrautzki S, et al. Among authors: ullrich s. Mol Metab. 2017 Oct;6(10):1304-1312. doi: 10.1016/j.molmet.2017.07.007. Epub 2017 Jul 18. Mol Metab. 2017. PMID: 29031729 Free PMC article.
Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion.
Panse M, Gerst F, Kaiser G, Teutsch CA, Dölker R, Wagner R, Häring HU, Ullrich S. Panse M, et al. Among authors: ullrich s. Cell Physiol Biochem. 2015;35(4):1537-45. doi: 10.1159/000373969. Epub 2015 Mar 12. Cell Physiol Biochem. 2015. PMID: 25792236 Free article.
Metabolic crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion.
Gerst F, Wagner R, Kaiser G, Panse M, Heni M, Machann J, Bongers MN, Sartorius T, Sipos B, Fend F, Thiel C, Nadalin S, Königsrainer A, Stefan N, Fritsche A, Häring HU, Ullrich S, Siegel-Axel D. Gerst F, et al. Among authors: ullrich s. Diabetologia. 2017 Nov;60(11):2240-2251. doi: 10.1007/s00125-017-4385-1. Epub 2017 Aug 8. Diabetologia. 2017. PMID: 28791439
641 results