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A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity.
Hagenstein J, Melderis S, Nosko A, Warkotsch MT, Richter JV, Ramcke T, Herrnstadt GR, Scheller J, Yan I, Mittrücker HW, Kluger MA, Steinmetz OM. Hagenstein J, et al. Among authors: scheller j. J Am Soc Nephrol. 2019 Aug;30(8):1439-1453. doi: 10.1681/ASN.2019020118. Epub 2019 Jul 16. J Am Soc Nephrol. 2019. PMID: 31311828 Free PMC article.
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J. Garbers C, et al. Among authors: scheller j. J Biol Chem. 2011 Dec 16;286(50):42959-70. doi: 10.1074/jbc.M111.295758. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990364 Free PMC article.
Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM. Luig M, et al. Among authors: scheller j. J Am Soc Nephrol. 2015 Jul;26(7):1597-607. doi: 10.1681/ASN.2014060620. Epub 2015 Feb 5. J Am Soc Nephrol. 2015. PMID: 25655068 Free PMC article.
IL-23R Signaling Plays No Role in Myocardial Infarction.
Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D, Alter C, Ding Z, Flögel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM, Scheller J. Engelowski E, et al. Among authors: scheller j. Sci Rep. 2018 Nov 20;8(1):17078. doi: 10.1038/s41598-018-35188-8. Sci Rep. 2018. PMID: 30459442 Free PMC article.
IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy.
Fazel Modares N, Polz R, Haghighi F, Lamertz L, Behnke K, Zhuang Y, Kordes C, Häussinger D, Sorg UR, Pfeffer K, Floss DM, Moll JM, Piekorz RP, Ahmadian MR, Lang PA, Scheller J. Fazel Modares N, et al. Among authors: scheller j. Hepatology. 2019 Dec;70(6):2075-2091. doi: 10.1002/hep.30774. Epub 2019 Jul 8. Hepatology. 2019. PMID: 31100194
236 results