Okombo J - Search Results

1

Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture.

Njoroge M, Kaur G, Espinoza-Moraga M, Wasuna A, Dziwornu GA, Seldon R, Taylor D, Okombo J, Warner DF, Chibale K. Njoroge M, et al. Among authors: okombo j. ACS Infect Dis. 2019 Sep 13;5(9):1634-1644. doi: 10.1021/acsinfecdis.9b00208. Epub 2019 Jul 29. ACS Infect Dis. 2019. PMID: 31309823

2

Chloroquine-containing compounds: a patent review (2010 - 2014).

Njaria PM, Okombo J, Njuguna NM, Chibale K. Njaria PM, et al. Among authors: okombo j. Expert Opin Ther Pat. 2015;25(9):1003-24. doi: 10.1517/13543776.2015.1050791. Epub 2015 Jun 1. Expert Opin Ther Pat. 2015. PMID: 26013494 Free PMC article. Review.

3

Antiplasmodial drug targets: a patent review (2000 - 2013).

Okombo J, Chibale K. Okombo J, et al. Expert Opin Ther Pat. 2016;26(1):107-30. doi: 10.1517/13543776.2016.1113258. Epub 2015 Nov 13. Expert Opin Ther Pat. 2016. PMID: 26566576 Review.

4

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.

Espinoza-Moraga M, Singh K, Njoroge M, Kaur G, Okombo J, De Kock C, Smith PJ, Wittlin S, Chibale K. Espinoza-Moraga M, et al. Among authors: okombo j. Bioorg Med Chem Lett. 2017 Feb 1;27(3):658-661. doi: 10.1016/j.bmcl.2016.11.077. Epub 2016 Nov 25. Bioorg Med Chem Lett. 2017. PMID: 28012840 Free article.

5

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K. Singh K, et al. Among authors: okombo j. J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7. J Med Chem. 2017. PMID: 28094524

6

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

Okombo J, Singh K, Mayoka G, Ndubi F, Barnard L, Njogu PM, Njoroge M, Gibhard L, Brunschwig C, Vargas M, Keiser J, Egan TJ, Chibale K. Okombo J, et al. ACS Infect Dis. 2017 Jun 9;3(6):411-420. doi: 10.1021/acsinfecdis.6b00205. Epub 2017 May 3. ACS Infect Dis. 2017. PMID: 28440625

7

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.

Okombo J, Chibale K. Okombo J, et al. Acc Chem Res. 2017 Jul 18;50(7):1606-1616. doi: 10.1021/acs.accounts.6b00631. Epub 2017 Jun 21. Acc Chem Res. 2017. PMID: 28636311 Free PMC article.

8

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.

Joshi MC, Okombo J, Nsumiwa S, Ndove J, Taylor D, Wiesner L, Hunter R, Chibale K, Egan TJ. Joshi MC, et al. Among authors: okombo j. J Med Chem. 2017 Dec 28;60(24):10245-10256. doi: 10.1021/acs.jmedchem.7b01537. Epub 2017 Dec 7. J Med Chem. 2017. PMID: 29185748

9

Recent updates in the discovery and development of novel antimalarial drug candidates.

Okombo J, Chibale K. Okombo J, et al. Medchemcomm. 2018 Feb 2;9(3):437-453. doi: 10.1039/c7md00637c. eCollection 2018 Mar 1. Medchemcomm. 2018. PMID: 30108934 Free PMC article. Review.

10

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates.

Okombo J, Chibale K. Okombo J, et al. Medchemcomm. 2018 Mar 2;9(3):590. doi: 10.1039/c8md90009d. eCollection 2018 Mar 1. Medchemcomm. 2018. PMID: 30288210 Free PMC article.

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