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Page 1
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease.
Morou A, Brunet-Ratnasingham E, Dubé M, Charlebois R, Mercier E, Darko S, Brassard N, Nganou-Makamdop K, Arumugam S, Gendron-Lepage G, Yang L, Niessl J, Baxter AE, Billingsley JM, Rajakumar PA, Lefebvre F, Johnson RP, Tremblay C, Routy JP, Wyatt RT, Finzi A, Douek DC, Kaufmann DE. Morou A, et al. Nat Immunol. 2019 Aug;20(8):1059-1070. doi: 10.1038/s41590-019-0418-x. Epub 2019 Jul 15. Nat Immunol. 2019. PMID: 31308541 Free PMC article.
Translocated microbiome composition determines immunological outcome in treated HIV infection.
Nganou-Makamdop K, Talla A, Sharma AA, Darko S, Ransier A, Laboune F, Chipman JG, Beilman GJ, Hoskuldsson T, Fourati S, Schmidt TE, Arumugam S, Lima NS, Moon D, Callisto S, Schoephoerster J, Tomalka J, Mugyenyi P, Ssali F, Muloma P, Ssengendo P, Leda AR, Cheu RK, Flynn JK, Morou A, Brunet-Ratnasingham E, Rodriguez B, Lederman MM, Kaufmann DE, Klatt NR, Kityo C, Brenchley JM, Schacker TW, Sekaly RP, Douek DC. Nganou-Makamdop K, et al. Cell. 2021 Jul 22;184(15):3899-3914.e16. doi: 10.1016/j.cell.2021.05.023. Epub 2021 Jul 7. Cell. 2021. PMID: 34237254 Free PMC article.
Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication.
Nganou-Makamdop K, Billingsley JM, Yaffe Z, O'Connor G, Tharp GK, Ransier A, Laboune F, Matus-Nicodemos R, Lerner A, Gharu L, Robertson JM, Ford ML, Schlapschy M, Kuhn N, Lensch A, Lifson J, Nason M, Skerra A, Schreiber G, Bosinger SE, Douek DC. Nganou-Makamdop K, et al. PLoS Pathog. 2018 Aug 24;14(8):e1007246. doi: 10.1371/journal.ppat.1007246. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30142226 Free PMC article.
Multiple Origins of Virus Persistence during Natural Control of HIV Infection.
Boritz EA, Darko S, Swaszek L, Wolf G, Wells D, Wu X, Henry AR, Laboune F, Hu J, Ambrozak D, Hughes MS, Hoh R, Casazza JP, Vostal A, Bunis D, Nganou-Makamdop K, Lee JS, Migueles SA, Koup RA, Connors M, Moir S, Schacker T, Maldarelli F, Hughes SH, Deeks SG, Douek DC. Boritz EA, et al. Cell. 2016 Aug 11;166(4):1004-1015. doi: 10.1016/j.cell.2016.06.039. Epub 2016 Jul 21. Cell. 2016. PMID: 27453467 Free PMC article.
Impact of Integrase Inhibition Compared With Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues.
Rothenberger M, Nganou-Makamdop K, Kityo C, Ssali F, Chipman JG, Beilman GJ, Hoskuldsson T, Anderson J, Jasurda J, Schmidt TE, Calisto SP, Pearson H, Reimann T, David C, Perkey K, Southern P, Wietgrefe S, Helgeson E, Reilly C, Haase AT, Douek DC, Fletcher CV, Schacker TW. Rothenberger M, et al. J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):355-360. doi: 10.1097/QAI.0000000000002026. J Acquir Immune Defic Syndr. 2019. PMID: 31192893 Free PMC article.
Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.
Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher CV, Beilman GJ, Chipman JG, Khoruts A, Estes JD, Anderson J, Callisto SP, Schmidt TE, Thorkelson A, Reilly C, Perkey K, Reimann TG, Utay NS, Nganou Makamdop K, Stevenson M, Douek DC, Haase AT, Schacker TW. Rothenberger MK, et al. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1126-34. doi: 10.1073/pnas.1414926112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713386 Free PMC article.
Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression.
Claiborne DT, Prince JL, Scully E, Macharia G, Micci L, Lawson B, Kopycinski J, Deymier MJ, Vanderford TH, Nganou-Makamdop K, Ende Z, Brooks K, Tang J, Yu T, Lakhi S, Kilembe W, Silvestri G, Douek D, Goepfert PA, Price MA, Allen SA, Paiardini M, Altfeld M, Gilmour J, Hunter E. Claiborne DT, et al. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1480-9. doi: 10.1073/pnas.1421607112. Epub 2015 Feb 17. Proc Natl Acad Sci U S A. 2015. PMID: 25730868 Free PMC article.
Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis.
Claiborne DT, Scully EP, Palmer CD, Prince JL, Macharia GN, Kopycinski J, Michelo CM, Wiener HW, Parker R, Nganou-Makamdop K, Douek D, Altfeld M, Gilmour J, Price MA, Tang J, Kilembe W, Allen SA, Hunter E. Claiborne DT, et al. Among authors: nganou makamdop k. PLoS Pathog. 2019 Aug 26;15(8):e1007981. doi: 10.1371/journal.ppat.1007981. eCollection 2019 Aug. PLoS Pathog. 2019. PMID: 31449552 Free PMC article.
Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1.
Shangguan S, Ehrenberg PK, Geretz A, Yum L, Kundu G, May K, Fourati S, Nganou-Makamdop K, Williams LD, Sawant S, Lewitus E, Pitisuttithum P, Nitayaphan S, Chariyalertsak S, Rerks-Ngarm S, Rolland M, Douek DC, Gilbert P, Tomaras GD, Michael NL, Vasan S, Thomas R. Shangguan S, et al. Among authors: nganou makamdop k. Elife. 2021 Sep 17;10:e69577. doi: 10.7554/eLife.69577. Elife. 2021. PMID: 34533134 Free PMC article.
26 results