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Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease.
Morou A, Brunet-Ratnasingham E, Dubé M, Charlebois R, Mercier E, Darko S, Brassard N, Nganou-Makamdop K, Arumugam S, Gendron-Lepage G, Yang L, Niessl J, Baxter AE, Billingsley JM, Rajakumar PA, Lefebvre F, Johnson RP, Tremblay C, Routy JP, Wyatt RT, Finzi A, Douek DC, Kaufmann DE. Morou A, et al. Among authors: douek dc. Nat Immunol. 2019 Aug;20(8):1059-1070. doi: 10.1038/s41590-019-0418-x. Epub 2019 Jul 15. Nat Immunol. 2019. PMID: 31308541 Free PMC article.
HIV preferentially infects HIV-specific CD4+ T cells.
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA. Douek DC, et al. Nature. 2002 May 2;417(6884):95-8. doi: 10.1038/417095a. Nature. 2002. PMID: 11986671
T cell dynamics in HIV-1 infection.
Douek DC, Picker LJ, Koup RA. Douek DC, et al. Annu Rev Immunol. 2003;21:265-304. doi: 10.1146/annurev.immunol.21.120601.141053. Epub 2001 Dec 19. Annu Rev Immunol. 2003. PMID: 12524385 Review.
HIV disease: fallout from a mucosal catastrophe?
Brenchley JM, Price DA, Douek DC. Brenchley JM, et al. Among authors: douek dc. Nat Immunol. 2006 Mar;7(3):235-9. doi: 10.1038/ni1316. Nat Immunol. 2006. PMID: 16482171 Review.
Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.
Duvall MG, Jaye A, Dong T, Brenchley JM, Alabi AS, Jeffries DJ, van der Sande M, Togun TO, McConkey SJ, Douek DC, McMichael AJ, Whittle HC, Koup RA, Rowland-Jones SL. Duvall MG, et al. Among authors: douek dc. J Immunol. 2006 Jun 1;176(11):6973-81. doi: 10.4049/jimmunol.176.11.6973. J Immunol. 2006. PMID: 16709858
Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC. Brenchley JM, et al. Among authors: douek dc. Nat Med. 2006 Dec;12(12):1365-71. doi: 10.1038/nm1511. Epub 2006 Nov 19. Nat Med. 2006. PMID: 17115046
445 results