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ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype.
Lucena-Araujo AR, Coelho-Silva JL, Pereira-Martins DA, Thomé C, Scheucher PS, Lange AP, Paiva HH, Hemmelgarn BT, Morais-Sobral MC, Azevedo EA, Franca-Neto PL, Franca RF, Silva CL, Krause A, Rego EM. Lucena-Araujo AR, et al. Oncotarget. 2017 Jan 31;8(5):8475-8483. doi: 10.18632/oncotarget.14295. Oncotarget. 2017. PMID: 28035072 Free PMC article.
Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms.
Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F. Machado-Neto JA, et al. Cell Death Dis. 2018 Feb 22;9(3):311. doi: 10.1038/s41419-017-0256-4. Cell Death Dis. 2018. PMID: 29472557 Free PMC article.
Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis.
Machado-Neto JA, Fenerich BA, Rodrigues Alves APN, Fernandes JC, Scopim-Ribeiro R, Coelho-Silva JL, Traina F. Machado-Neto JA, et al. Clinics (Sao Paulo). 2018 Oct 11;73(suppl 1):e566s. doi: 10.6061/clinics/2018/e566s. Clinics (Sao Paulo). 2018. PMID: 30328953 Free PMC article. Review.
Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia.
Lucena-Araujo AR, Coelho-Silva JL, Pereira-Martins DA, Silveira DR, Koury LC, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria AB, Kerbauy F, de Lourdes Chauffaille M, Bendit I, Rocha V, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk PJM, Lo-Coco F, Sanz MA, Berliner N, Rego EM. Lucena-Araujo AR, et al. Blood. 2019 Sep 19;134(12):951-959. doi: 10.1182/blood.2019000239. Epub 2019 Jul 10. Blood. 2019. PMID: 31292112 Free PMC article.
Co-occurrence of DNMT3A, NPM1, FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis.
Bezerra MF, Lima AS, Piqué-Borràs MR, Silveira DR, Coelho-Silva JL, Pereira-Martins DA, Weinhäuser I, Franca-Neto PL, Quek L, Corby A, Oliveira MM, Lima MM, de Assis RA, de Melo Campos P, Duarte BK, Bendit I, Rocha V, Rego EM, Traina F, Saad ST, Beltrão EI, Bezerra MA, Lucena-Araujo AR. Bezerra MF, et al. Blood. 2020 Mar 12;135(11):870-875. doi: 10.1182/blood.2019003339. Blood. 2020. PMID: 31977039 Free article. No abstract available.
NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells.
Fenerich BA, Fernandes JC, Rodrigues Alves APN, Coelho-Silva JL, Scopim-Ribeiro R, Scheucher PS, Eide CA, Tognon CE, Druker BJ, Rego EM, Machado-Neto JA, Traina F. Fenerich BA, et al. Signal Transduct Target Ther. 2020 Jan 24;5(1):5. doi: 10.1038/s41392-019-0102-5. Signal Transduct Target Ther. 2020. PMID: 32296029 Free PMC article.
38 results