Wright MR - Search Results

1

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Zhang D, Hop CECA, Patilea-Vrana G, Gampa G, Seneviratne HK, Unadkat JD, Kenny JR, Nagapudi K, Di L, Zhou L, Zak M, Wright MR, Bumpus NN, Zang R, Liu X, Lai Y, Khojasteh SC. Zhang D, et al. Among authors: wright mr. Drug Metab Dispos. 2019 Oct;47(10):1122-1135. doi: 10.1124/dmd.119.086744. Epub 2019 Jul 2. Drug Metab Dispos. 2019. PMID: 31266753 Free PMC article. Review.

2

Rational use of plasma protein and tissue binding data in drug design.

Liu X, Wright M, Hop CE. Liu X, et al. J Med Chem. 2014 Oct 23;57(20):8238-48. doi: 10.1021/jm5007935. Epub 2014 Aug 6. J Med Chem. 2014. PMID: 25099658 Review.

3

Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib.

Lin L, Wright MR, Hop CECA, Wong H. Lin L, et al. Among authors: wright mr. Drug Metab Dispos. 2022 Sep;50(9):1170-1181. doi: 10.1124/dmd.122.000885. Epub 2022 Jul 2. Drug Metab Dispos. 2022. PMID: 35779865

4

Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis.

Chen YC, Kenny JR, Wright M, Hop CECA, Yan Z. Chen YC, et al. J Pharm Sci. 2019 Mar;108(3):1296-1302. doi: 10.1016/j.xphs.2018.10.011. Epub 2018 Oct 14. J Pharm Sci. 2019. PMID: 30326208

5

Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947.

Liu X, Liang X, LeCouter J, Ubhayakar S, Chen J, Cheng J, Lee T, Lubach J, Nonomiya J, Shahidi-Latham S, Quiason C, Solon E, Wright M, Hop CECA, Heffron TP. Liu X, et al. Drug Metab Dispos. 2020 May;48(5):408-419. doi: 10.1124/dmd.119.089763. Epub 2020 Mar 4. Drug Metab Dispos. 2020. PMID: 32132091

6

Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST).

Takahashi RH, Khojasteh C, Wright M, Hop CECA, Ma S. Takahashi RH, et al. Drug Metab Lett. 2017 Nov 17;11(1):21-28. doi: 10.2174/1872312811666170710193229. Drug Metab Lett. 2017. PMID: 28699487

7

Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins.

Chow TW, Wright MR, Hop CECA, Wong H. Chow TW, et al. Among authors: wright mr. Xenobiotica. 2019 Dec;49(12):1423-1433. doi: 10.1080/00498254.2019.1571651. Epub 2019 Feb 22. Xenobiotica. 2019. PMID: 30794022

8

Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs.

Zhang D, Wei C, Hop CECA, Wright MR, Hu M, Lai Y, Khojasteh SC, Humphreys WG. Zhang D, et al. Among authors: wright mr. J Med Chem. 2021 Jun 10;64(11):7045-7059. doi: 10.1021/acs.jmedchem.0c01720. Epub 2021 May 19. J Med Chem. 2021. PMID: 34010555 Review.

9

Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis.

Wong H, Liu L, Ouyang W, Deng Y, Wright MR, Hop CECA. Wong H, et al. Among authors: wright mr. J Pharmacol Exp Ther. 2019 Jun;369(3):406-418. doi: 10.1124/jpet.118.255562. Epub 2019 Apr 2. J Pharmacol Exp Ther. 2019. PMID: 30940693

10

Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling.

Mao J, Doshi U, Wright M, Hop CECA, Li AP, Chen Y. Mao J, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Apr;7(4):251-258. doi: 10.1002/psp4.12283. Epub 2018 Feb 13. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29388346 Free PMC article.

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