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A novel class of selective CK2 inhibitors targeting its open hinge conformation.
Dalle Vedove A, Zonta F, Zanforlin E, Demitri N, Ribaudo G, Cazzanelli G, Ongaro A, Sarno S, Zagotto G, Battistutta R, Ruzzene M, Lolli G. Dalle Vedove A, et al. Among authors: lolli g. Eur J Med Chem. 2020 Jun 1;195:112267. doi: 10.1016/j.ejmech.2020.112267. Epub 2020 Mar 25. Eur J Med Chem. 2020. PMID: 32283296
Pharmacological inactivation of the prion protein by targeting a folding intermediate.
Spagnolli G, Massignan T, Astolfi A, Biggi S, Rigoli M, Brunelli P, Libergoli M, Ianeselli A, Orioli S, Boldrini A, Terruzzi L, Bonaldo V, Maietta G, Lorenzo NL, Fernandez LC, Codeseira YB, Tosatto L, Linsenmeier L, Vignoli B, Petris G, Gasparotto D, Pennuto M, Guella G, Canossa M, Altmeppen HC, Lolli G, Biressi S, Pastor MM, Requena JR, Mancini I, Barreca ML, Faccioli P, Biasini E. Spagnolli G, et al. Among authors: lolli g. Commun Biol. 2021 Jan 12;4(1):62. doi: 10.1038/s42003-020-01585-x. Commun Biol. 2021. PMID: 33437023 Free PMC article.
Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing.
Dalle Vedove A, Cazzanelli G, Batiste L, Marchand JR, Spiliotopoulos D, Corsi J, D'Agostino VG, Caflisch A, Lolli G. Dalle Vedove A, et al. Among authors: lolli g. ACS Med Chem Lett. 2022 Aug 3;13(9):1434-1443. doi: 10.1021/acsmedchemlett.2c00173. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105334 Free PMC article.
Identification of a BAZ2A Bromodomain Hit Compound by Fragment Joining.
Dalle Vedove A, Cazzanelli G, Corsi J, Sedykh M, D'Agostino VG, Caflisch A, Lolli G. Dalle Vedove A, et al. Among authors: lolli g. ACS Bio Med Chem Au. 2021 Dec 15;1(1):5-10. doi: 10.1021/acsbiomedchemau.1c00016. Epub 2021 Jul 7. ACS Bio Med Chem Au. 2021. PMID: 36147311 Free PMC article.
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6-Methyladenosine-Modified RNAs.
Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A. Micaelli M, et al. Among authors: lolli g. ACS Pharmacol Transl Sci. 2022 Sep 14;5(10):872-891. doi: 10.1021/acsptsci.2c00008. eCollection 2022 Oct 14. ACS Pharmacol Transl Sci. 2022. PMID: 36268123 Free PMC article.
190 results