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Page 1
Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
Kennedy L, Francis H, Invernizzi P, Venter J, Wu N, Carbone M, Gershwin ME, Bernuzzi F, Franchitto A, Alvaro D, Marzioni M, Onori P, Gaudio E, Sybenga A, Fabris L, Meng F, Glaser S, Alpini G. Kennedy L, et al. Among authors: sybenga a. FASEB J. 2019 Sep;33(9):10269-10279. doi: 10.1096/fj.201802606R. Epub 2019 Jun 28. FASEB J. 2019. PMID: 31251081 Free PMC article.
In dnTGF-betaRII mice, there was increased microRNA-125b/TGF-beta1/TGF-beta receptor 1/VEGF-A signaling. Human early-stage PBC patients had an increase in hepatobiliary Sct and SR expression and serum Sct levels. ...-Kennedy, L., Francis, H., Invernizzi, P., Venter, J., Wu …
In dnTGF-betaRII mice, there was increased microRNA-125b/TGF-beta1/TGF-beta receptor 1/VEGF-A signaling. Human early-stage PBC patien …
Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling.
Kennedy L, Hargrove L, Demieville J, Bailey JM, Dar W, Polireddy K, Chen Q, Nevah Rubin MI, Sybenga A, DeMorrow S, Meng F, Stockton L, Alpini G, Francis H. Kennedy L, et al. Among authors: sybenga a. Am J Pathol. 2018 Mar;188(3):600-615. doi: 10.1016/j.ajpath.2017.11.016. Epub 2017 Dec 15. Am J Pathol. 2018. PMID: 29248461 Free PMC article.
Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2-/- mice and human primary sclerosing cholangitis.
Meng F, Kennedy L, Hargrove L, Demieville J, Jones H, Madeka T, Karstens A, Chappell K, Alpini G, Sybenga A, Invernizzi P, Bernuzzi F, DeMorrow S, Francis H. Meng F, et al. Among authors: sybenga a. Lab Invest. 2018 Nov;98(11):1465-1477. doi: 10.1038/s41374-018-0101-0. Epub 2018 Aug 24. Lab Invest. 2018. PMID: 30143751 Free PMC article.
Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes.
Wan Y, Ceci L, Wu N, Zhou T, Chen L, Venter J, Francis H, Bernuzzi F, Invernizzi P, Kyritsi K, Baker P, Huang Q, Wu C, Sybenga A, Alpini G, Meng F, Glaser S. Wan Y, et al. Among authors: sybenga a. Lab Invest. 2019 Jun;99(6):764-776. doi: 10.1038/s41374-018-0178-5. Epub 2019 Jan 30. Lab Invest. 2019. PMID: 30700848 Free PMC article.
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
Chen L, Zhou T, Wu N, O'Brien A, Venter J, Ceci L, Kyritsi K, Onori P, Gaudio E, Sybenga A, Xie L, Wu C, Fabris L, Invernizzi P, Zawieja D, Liangpunsakul S, Meng F, Francis H, Alpini G, Huang Q, Glaser S. Chen L, et al. Among authors: sybenga a. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1525-1539. doi: 10.1016/j.bbadis.2019.03.002. Epub 2019 Mar 16. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30890428 Free PMC article.
Knockout of the Tachykinin Receptor 1 in the Mdr2-/- (Abcb4-/-) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis.
Ceci L, Francis H, Zhou T, Giang T, Yang Z, Meng F, Wu N, Kennedy L, Kyritsi K, Meadows V, Wu C, Liangpunsakul S, Franchitto A, Sybenga A, Ekser B, Mancinelli R, Onori P, Gaudio E, Glaser S, Alpini G. Ceci L, et al. Among authors: sybenga a. Am J Pathol. 2020 Nov;190(11):2251-2266. doi: 10.1016/j.ajpath.2020.07.007. Epub 2020 Jul 23. Am J Pathol. 2020. PMID: 32712019 Free PMC article.
Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC).
Zhou T, Kyritsi K, Wu N, Francis H, Yang Z, Chen L, O'Brien A, Kennedy L, Ceci L, Meadows V, Kusumanchi P, Wu C, Baiocchi L, Skill NJ, Saxena R, Sybenga A, Xie L, Liangpunsakul S, Meng F, Alpini G, Glaser S. Zhou T, et al. Among authors: sybenga a. EBioMedicine. 2019 Oct;48:130-142. doi: 10.1016/j.ebiom.2019.09.013. Epub 2019 Sep 12. EBioMedicine. 2019. PMID: 31522982 Free PMC article.
Mast Cells Promote Nonalcoholic Fatty Liver Disease Phenotypes and Microvesicular Steatosis in Mice Fed a Western Diet.
Kennedy L, Meadows V, Sybenga A, Demieville J, Chen L, Hargrove L, Ekser B, Dar W, Ceci L, Kundu D, Kyritsi K, Pham L, Zhou T, Glaser S, Meng F, Alpini G, Francis H. Kennedy L, et al. Among authors: sybenga a. Hepatology. 2021 Jul;74(1):164-182. doi: 10.1002/hep.31713. Epub 2021 May 24. Hepatology. 2021. PMID: 33434322 Free PMC article.
Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Chen L, Wu N, Kennedy L, Francis H, Ceci L, Zhou T, Samala N, Kyritsi K, Wu C, Sybenga A, Ekser B, Dar W, Atkins C, Meadows V, Glaser S, Alpini G. Chen L, et al. Among authors: sybenga a. Hepatology. 2021 Oct;74(4):1845-1863. doi: 10.1002/hep.31871. Epub 2021 Jul 29. Hepatology. 2021. PMID: 33928675 Free PMC article.
20 results