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The S. cerevisiae cation translocation protein Trk1 is functional without its "long hydrophilic loop" but LHL regulates cation translocation activity and selectivity.
Kale D, Spurny P, Shamayeva K, Spurna K, Kahoun D, Ganser D, Zayats V, Ludwig J. Kale D, et al. Among authors: zayats v. Biochim Biophys Acta Biomembr. 2019 Aug 1;1861(8):1476-1488. doi: 10.1016/j.bbamem.2019.06.010. Epub 2019 Jun 21. Biochim Biophys Acta Biomembr. 2019. PMID: 31229587 Free article.
A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.
Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodová B, Pammer T, Litviňuková M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R. Frischauf I, et al. Among authors: zayats v. Sci Signal. 2015 Dec 22;8(408):ra131. doi: 10.1126/scisignal.aab1901. Sci Signal. 2015. PMID: 26696631 Free PMC article.
Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R. Frischauf I, et al. Among authors: zayats v. Sci Signal. 2017 Nov 28;10(507):eaao0358. doi: 10.1126/scisignal.aao0358. Sci Signal. 2017. PMID: 29184031 Free PMC article.
Cholesterol modulates Orai1 channel function.
Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C. Derler I, et al. Among authors: zayats v. Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808. Sci Signal. 2016. PMID: 26814231 Free PMC article.
17 results